Valuation: ISIS Pharmaceuticals, Inc.

Market Cap 7.57B 6.68B 6.32B 5.73B 10.75B 727B 10.86B 75.86B 29.24B 371B 28.44B 27.82B 1,194B P/E 2026 *
-12.7x
P/E 2027 * -23.4x
Enterprise Value 7.47B 6.59B 6.24B 5.66B 10.61B 717B 10.71B 74.83B 28.84B 366B 28.05B 27.44B 1,178B EV / Sales 2026 *
8.12x
EV / Sales 2027 * 5.6x
Free-Float
99.05%
Yield 2026 *
-
Yield 2027 * -
Manager TitleAgeSince
Investor Relations Contact 60 2012-06-30
Chief Executive Officer 64 2019-12-31
Director of Finance/CFO 64 2000-04-30
Director TitleAgeSince
Director/Board Member 64 2005-12-12
Director/Board Member 73 2002-04-30
Director/Board Member 64 2019-03-24
Change 5-day change 1-year change 3-year change Capi.($)
+1.33%+2.73% - - 7.57B
-0.03%+6.41%+11.83%+38.36% 49.06B
-0.73%-0.41%+48.84%+36.72% 44.6B
+1.36%+6.03%+343.85%+638.73% 43.24B
-0.47%-0.76%+9.75%+103.07% 41.73B
+0.34%-1.38%+5.53%+47.36% 29.93B
+1.00%-1.28%+24.23%+156.93% 17.19B
-2.94%+6.98%+5.10% - 15.35B
-3.20%-2.38%+25.00%+43.67% 15.54B
-0.86%-4.00% - - 15.11B
Average -0.55%+1.76%+59.27%+152.12% 30.19B
Weighted average by Cap. -0.43%+2.17%+74.36%+166.74%

Financials

2026 *2027 *
Net sales 920M 811M 768M 696M 1.31B 88.24B 1.32B 9.21B 3.55B 45.06B 3.45B 3.38B 145B 1.36B 1.2B 1.14B 1.03B 1.94B 131B 1.96B 13.67B 5.27B 66.87B 5.12B 5.01B 215B
Net income -576M -509M -481M -436M -818M -55.29B -826M -5.77B -2.22B -28.24B -2.16B -2.12B -90.86B -330M -291M -276M -250M -469M -31.68B -473M -3.31B -1.27B -16.18B -1.24B -1.21B -52.06B
Net Debt -103M -90.89M -85.99M -77.99M -146M -9.88B -148M -1.03B -398M -5.05B -387M -378M -16.24B 68.31M 60.28M 57.04M 51.73M 96.98M 6.55B 97.93M 684M 264M 3.35B 256M 251M 10.77B
Logo ISIS Pharmaceuticals, Inc.
Ionis Pharmaceuticals, Inc. develops six marketed medicines for serious diseases, including medicines for neurologic and cardiovascular diseases. Its marketed medicines consist of TRYNGOLZA, WAINUA (eplontersen), SPINRAZA (nusinersen), QALSODY (tofersen), TEGSEDI (inotersen) and WAYLIVRA (volanesorsen). TRYNGOLZA reduces triglyceride levels in adults with familial chylomicronemia syndrome (FCS). WAINUA is approved for the treatment of the polyneuropathy of hereditary transthyretin-medicated amyloidosis (ATTRv-PN) in adults. SPINRAZA is used for the treatment of pediatric and adult patients with spinal muscular atrophy. QALSODY is approved for the treatment of Amyotrophic Lateral Sclerosis in adults who have a mutation in the superoxide dismutase 1 (SOD1) gene, or SOD1-ALS. TEGSEDI is approved for the treatment of ATTRv-PN in adults. WAYLIVRA is approved as an adjunct to diet in adult patients with genetically confirmed FCS and at high risk of acute, potentially fatal pancreatitis.
Employees
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