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Valuation: ISIS Pharmaceuticals, Inc.

Market Cap 12.11B 10.43B 9.61B 9.01B 16.91B 1,152B 17.11B 114B 44.23B 560B 45.44B 44.48B 1,936B P/E Ratio 2026 *
-20.3x
P/E Ratio 2027 * -58.5x
Enterprise Value 11.89B 10.24B 9.43B 8.84B 16.6B 1,131B 16.79B 112B 43.42B 550B 44.61B 43.66B 1,901B EV / Sales 2026 *
13.4x
EV / Sales 2027 * 7.91x
Free-Float
99.08%
Yield 2026 *
-
Yield 2027 * -
Manager TitleAgeSince
Investor Relations Contact 60 2012-06-30
Chief Executive Officer 64 2019-12-31
Director of Finance/CFO 64 2000-04-30
Director TitleAgeSince
Director/Board Member 64 2005-12-12
Director/Board Member 73 2002-04-30
Director/Board Member 64 2019-03-24
Change 5-day change 1-year change 3-year change Capi.($)
+1.33%+2.73% - - 12.11B
-0.35%+0.97%-13.80%-13.25% 43.03B
+3.11%+3.11%+279.08%+501.52% 32.71B
+0.22%-1.08%+15.66%-15.65% 30.29B
+1.62%-2.08%-1.91%+24.64% 29.4B
+4.09%+0.93%+12.97%+20.22% 25.08B
+1.14%+3.62% - - 13.54B
-1.63%+2.88%+56.69%+113.41% 13.35B
-0.40%-1.29%+6.23%+7.63% 12.97B
-2.49%-2.19%+0.36%-36.74% 11.19B
Average +0.66%+1.39%+44.41%+75.22% 23.51B
Weighted average by Cap. +0.98%+1.46%+51.11%+89.87%

Financials

2026 *2027 *
Net sales 890M 767M 706M 662M 1.24B 84.66B 1.26B 8.36B 3.25B 41.17B 3.34B 3.27B 142B 1.49B 1.28B 1.18B 1.11B 2.08B 142B 2.11B 14.02B 5.45B 68.99B 5.6B 5.48B 239B
Net income -595M -512M -472M -442M -830M -56.55B -840M -5.59B -2.17B -27.5B -2.23B -2.18B -95.07B -215M -185M -171M -160M -300M -20.44B -304M -2.02B -785M -9.94B -807M -789M -34.36B
Net Debt -222M -191M -176M -165M -310M -21.1B -313M -2.08B -810M -10.26B -832M -815M -35.46B -308M -265M -244M -229M -430M -29.29B -435M -2.89B -1.12B -14.24B -1.16B -1.13B -49.23B
Logo ISIS Pharmaceuticals, Inc.
Ionis Pharmaceuticals, Inc. develops six marketed medicines for serious diseases, including medicines for neurologic and cardiovascular diseases. Its marketed medicines consist of TRYNGOLZA, WAINUA (eplontersen), SPINRAZA (nusinersen), QALSODY (tofersen), TEGSEDI (inotersen) and WAYLIVRA (volanesorsen). TRYNGOLZA reduces triglyceride levels in adults with familial chylomicronemia syndrome (FCS). WAINUA is approved for the treatment of the polyneuropathy of hereditary transthyretin-medicated amyloidosis (ATTRv-PN) in adults. SPINRAZA is used for the treatment of pediatric and adult patients with spinal muscular atrophy. QALSODY is approved for the treatment of Amyotrophic Lateral Sclerosis in adults who have a mutation in the superoxide dismutase 1 (SOD1) gene, or SOD1-ALS. TEGSEDI is approved for the treatment of ATTRv-PN in adults. WAYLIVRA is approved as an adjunct to diet in adult patients with genetically confirmed FCS and at high risk of acute, potentially fatal pancreatitis.
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