Valuation : ISIS Pharmaceuticals, Inc.

Market Cap 9.65B 8.31B 7.82B 7.14B 13.36B 911B 13.39B 92.36B 35.84B 468B 36.25B 35.46B 1,507B P/E 2026 *
-16x
P/E 2027 * -31.6x
Enterprise Value 9.55B 8.22B 7.73B 7.06B 13.21B 902B 13.25B 91.37B 35.46B 463B 35.86B 35.08B 1,490B EV / Sales 2026 *
10.5x
EV / Sales 2027 * 6.92x
Free-Float
99.05%
Yield 2026 *
-
Yield 2027 * -

Last Transcript : ISIS Pharmaceuticals, Inc.

Manager TitleAgeSince
Investor Relations Contact 60 2012-06-30
Chief Executive Officer 64 2019-12-31
Director of Finance/CFO 64 2000-04-30
Director TitleAgeSince
Director/Board Member 64 2005-12-12
Director/Board Member 73 2002-04-30
Director/Board Member 64 2019-03-24
Change 5-day change 1-year change 3-year change Capi.($)
+1.33%+2.73% - - 9.65B
-2.54%-2.84%-1.77%+14.33% 48.93B
-0.40%+1.03%+418.57%+527.30% 45.01B
-1.42%+2.30%+42.67%+22.37% 44.07B
-1.22%-2.31%+4.82%+77.49% 40.73B
+0.53%-1.36%+16.87%+46.82% 33.52B
-0.21%+9.14% - - 17.77B
-0.35%-1.56%+21.42%+120.75% 16.5B
-1.01%+0.50%+13.91%+31.83% 14.67B
-1.65%-1.03%+75.93%+41.12% 13.77B
Average -0.69%+0.53%+74.05%+110.25% 30.55B
Weighted average by Cap. -0.95%+0.11%+89.42%+128.98%

Financials

2026 *2027 *
Net sales 913M 786M 739M 676M 1.26B 86.24B 1.27B 8.74B 3.39B 44.24B 3.43B 3.35B 143B 1.4B 1.21B 1.14B 1.04B 1.94B 132B 1.95B 13.42B 5.21B 67.95B 5.27B 5.15B 219B
Net income -585M -503M -473M -432M -809M -55.19B -811M -5.59B -2.17B -28.32B -2.19B -2.15B -91.22B -314M -270M -254M -232M -434M -29.61B -435M -3B -1.16B -15.19B -1.18B -1.15B -48.94B
Net Debt -103M -88.66M -83.42M -76.2M -143M -9.73B -143M -986M -383M -4.99B -387M -378M -16.08B 56.88M 48.95M 46.05M 42.07M 78.7M 5.37B 78.92M 544M 211M 2.76B 214M 209M 8.88B
Logo ISIS Pharmaceuticals, Inc.
Ionis Pharmaceuticals, Inc. develops six marketed medicines for serious diseases, including medicines for neurologic and cardiovascular diseases. Its marketed medicines consist of TRYNGOLZA, WAINUA (eplontersen), SPINRAZA (nusinersen), QALSODY (tofersen), TEGSEDI (inotersen) and WAYLIVRA (volanesorsen). TRYNGOLZA reduces triglyceride levels in adults with familial chylomicronemia syndrome (FCS). WAINUA is approved for the treatment of the polyneuropathy of hereditary transthyretin-medicated amyloidosis (ATTRv-PN) in adults. SPINRAZA is used for the treatment of pediatric and adult patients with spinal muscular atrophy. QALSODY is approved for the treatment of Amyotrophic Lateral Sclerosis in adults who have a mutation in the superoxide dismutase 1 (SOD1) gene, or SOD1-ALS. TEGSEDI is approved for the treatment of ATTRv-PN in adults. WAYLIVRA is approved as an adjunct to diet in adult patients with genetically confirmed FCS and at high risk of acute, potentially fatal pancreatitis.
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