Valuation: ISIS Pharmaceuticals, Inc.

Market Cap 13.52B 11.82B 10.86B 10.12B 19.2B 1,287B 19.49B 130B 50.69B 633B 50.74B 49.65B 2,180B P/E 2026 *
-22.7x
P/E 2027 * -65x
Enterprise Value 13.3B 11.63B 10.68B 9.96B 18.89B 1,266B 19.18B 128B 49.86B 622B 49.92B 48.85B 2,145B EV / Sales 2026 *
14.9x
EV / Sales 2027 * 8.89x
Free-Float
99.09%
Yield 2026 *
-
Yield 2027 * -

Last Transcript: ISIS Pharmaceuticals, Inc.

Manager TitleAgeSince
Investor Relations Contact 60 2012-06-30
Chief Executive Officer 64 2019-12-31
Director of Finance/CFO 64 2000-04-30
Director TitleAgeSince
Director/Board Member 64 2005-12-12
Director/Board Member 73 2002-04-30
Director/Board Member 64 2019-03-24
Change 5-day change 1-year change 3-year change Capi.($)
+1.33%+2.73% - - 13.52B
+1.70%+7.41%+3.12%+8.46% 49.92B
+0.92%+3.93%+399.71%+605.33% 40.23B
+1.89%+8.32%+26.06%-6.35% 34.55B
+2.38%+6.35%+21.25%+64.58% 33.09B
+3.96%+10.67%+11.89%+38.86% 27.51B
+2.51%+5.27% - - 17.05B
+2.58%+5.79%+73.44%+133.27% 15.92B
+0.32%+0.58%+13.67%+19.09% 13.86B
-1.14%+1.88%+15.30%-28.79% 13.26B
Average +1.64%+6.17%+70.55%+104.31% 27.27B
Weighted average by Cap. +1.80%+6.70%+86.40%+130.36%

Financials

2026 *2027 *
Net sales 893M 781M 718M 669M 1.27B 85.07B 1.29B 8.62B 3.35B 41.81B 3.35B 3.28B 144B 1.51B 1.32B 1.21B 1.13B 2.14B 143B 2.17B 14.52B 5.64B 70.44B 5.65B 5.53B 243B
Net income -598M -523M -481M -448M -850M -56.98B -863M -5.77B -2.24B -28.01B -2.25B -2.2B -96.51B -199M -174M -160M -149M -282M -18.91B -286M -1.92B -744M -9.29B -745M -729M -32.02B
Net Debt -220M -192M -177M -165M -313M -20.95B -317M -2.12B -825M -10.3B -826M -808M -35.49B -138M -121M -111M -103M -196M -13.16B -199M -1.33B -518M -6.47B -519M -507M -22.28B
Logo ISIS Pharmaceuticals, Inc.
Ionis Pharmaceuticals, Inc. develops six marketed medicines for serious diseases, including medicines for neurologic and cardiovascular diseases. Its marketed medicines consist of TRYNGOLZA, WAINUA (eplontersen), SPINRAZA (nusinersen), QALSODY (tofersen), TEGSEDI (inotersen) and WAYLIVRA (volanesorsen). TRYNGOLZA reduces triglyceride levels in adults with familial chylomicronemia syndrome (FCS). WAINUA is approved for the treatment of the polyneuropathy of hereditary transthyretin-medicated amyloidosis (ATTRv-PN) in adults. SPINRAZA is used for the treatment of pediatric and adult patients with spinal muscular atrophy. QALSODY is approved for the treatment of Amyotrophic Lateral Sclerosis in adults who have a mutation in the superoxide dismutase 1 (SOD1) gene, or SOD1-ALS. TEGSEDI is approved for the treatment of ATTRv-PN in adults. WAYLIVRA is approved as an adjunct to diet in adult patients with genetically confirmed FCS and at high risk of acute, potentially fatal pancreatitis.
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