Valuation: Ionis Pharmaceuticals, Inc.

Capitalization 12.36B 10.66B 9.92B 9.24B 17.2B 1,122B 18.5B 114B 45B 535B 46.36B 45.41B 1,954B P/E ratio 2025 *
-33.7x
P/E ratio 2026 * -25.2x
Enterprise value 11.42B 9.84B 9.16B 8.53B 15.88B 1,036B 17.09B 105B 41.56B 494B 42.82B 41.94B 1,804B EV / Sales 2025 *
12.7x
EV / Sales 2026 * 12.7x
Free-Float
99.23%
Yield 2025 *
-
Yield 2026 * -
More valuation ratios * Estimated data
Dynamic Chart
1 day-1.14%
1 week-4.94%
Current month-3.51%
1 month-0.97%
3 months+4.43%
6 months+81.01%
Current year-3.51%
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1 week 74.49
Extreme 74.49
82.57
1 month 74.49
Extreme 74.49
86.15
Current year 74.49
Extreme 74.49
86.15
1 year 23.95
Extreme 23.95
86.15
3 years 23.95
Extreme 23.95
86.15
5 years 23.95
Extreme 23.95
86.15
10 years 19.59
Extreme 19.5927
86.58
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Manager TitleAgeSince
Investor Relations Contact 60 2012-06-30
Chief Executive Officer 64 2019-12-31
Director of Finance/CFO 64 2000-04-30
Director TitleAgeSince
Director/Board Member 71 2000-08-31
Director/Board Member 81 1993-12-31
Director/Board Member 64 2005-12-12
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Change 5d. change 1-year change 3-years change Capi.($)
-1.14%-4.94%+142.86%+91.78% 12.36B
-0.89%+1.01%+0.87%+12.27% 48.93B
-1.49%-1.95%+20.43%+7.29% 40.48B
-0.03%+0.09%+60.98%+26.34% 37.42B
-0.71%-3.69%+20.76%+39.59% 31.03B
-2.43%+1.38%+198.54%+339.30% 23.25B
-1.16%+2.67%+81.09%+167.21% 17.21B
Average -1.12%-0.58%+75.07%+97.68% 30.1B
Weighted average by Cap. -1.03%-0.39%+54.93%+71.25%
See all sector performances

Financials

2025 *2026 *
Net sales 897M 773M 720M 670M 1.25B 81.38B 1.34B 8.28B 3.26B 38.82B 3.36B 3.29B 142B 916M 789M 735M 684M 1.27B 83.07B 1.37B 8.45B 3.33B 39.62B 3.43B 3.36B 145B
Net income -356M -307M -286M -266M -495M -32.3B -533M -3.29B -1.3B -15.41B -1.33B -1.31B -56.26B -489M -421M -392M -365M -680M -44.34B -731M -4.51B -1.78B -21.15B -1.83B -1.79B -77.23B
Net Debt -946M -815M -759M -706M -1.32B -85.79B -1.42B -8.73B -3.44B -40.92B -3.55B -3.47B -149B -747M -644M -600M -558M -1.04B -67.8B -1.12B -6.9B -2.72B -32.34B -2.8B -2.74B -118B
More financial data * Estimated data
Logo Ionis Pharmaceuticals, Inc.
Ionis Pharmaceuticals, Inc. is engaged in ribonucleic acid (RNA)-targeted therapeutics. The Company has five marketed medicines and a pipeline in neurology, cardiology, and other areas of high patient need. It has nine medicines in Phase III development and multiple additional medicines in early and mid-stage development. The Company’s products include SPINRAZA, QALSODY, WAINUA, TEGSEDI and WAYLIVRA. SPINRAZA is used for the treatment of patients with spinal muscular atrophy (SMA), a progressive, debilitating and often fatal genetic disease. QALSODY is an antisense medicine that is used for the treatment of adult patients with superoxide dismutase 1 amyotrophic lateral sclerosis (SOD1-ALS), a rare, neurodegenerative disorder that causes progressive loss of motor neurons leading to death. WAINUA is a self-administered subcutaneous LIgand-Conjugated Antisense (LICA) medicine used for the treatment of adults with polyneuropathy of hereditary transthyretin-mediated amyloidosis (ATTRv-PN).
Employees
1,069
More about the company
Date Price Change Volume
26-01-16 76.33 $ -1.14% 3,000,587
26-01-15 77.21 $ -2.10% 1,409,021
26-01-14 78.87 $ -0.77% 2,121,498
26-01-13 79.48 $ -2.67% 1,885,179
26-01-12 81.66 $ +1.69% 1,570,607

Delayed Quote Nasdaq, January 16, 2026 at 04:00 pm

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Sell
Consensus
Buy
Mean consensus
BUY
Number of Analysts
22
Last Close Price
76.33USD
Average target price
90.63USD
Spread / Average Target
+18.73%
Consensus

Quarterly revenue - Rate of surprise