Valuation: Silence Therapeutics plc

Market Cap 392M 523M 465M 431M 739M 49.6B 751M 5.18B 2.03B 25.88B 1.96B 1.92B 82.51B P/E 2026 *
-17x
P/E 2027 * -14x
Enterprise Value 259M 345M 307M 284M 488M 32.75B 496M 3.42B 1.34B 17.09B 1.3B 1.27B 54.48B EV / Sales 2026 *
796x
EV / Sales 2027 * 290x
Free-Float
69.35%
Yield 2026 *
-
Yield 2027 * -
Manager TitleAgeSince
Chief Executive Officer 72 2025-11-30
Director of Finance/CFO 54 2022-01-31
Chief Tech/Sci/R&D Officer - 2020-12-31
Director TitleAgeSince
Director/Board Member 63 2018-06-20
Chairman 72 2003-12-31
Director/Board Member 65 2025-05-04
Change 5-day change 1-year change 3-year change Capi.($)
-6.60%-8.56%+49.38%+63.51% 65B
+0.03%+5.56%+9.10%+69.05% 51.2B
-4.09%-0.11%+2.22%+53.15% 51.19B
-1.53%+2.70%+30.48%+34.12% 43.93B
-1.34%+4.12%+16.64%+115.13% 41.96B
-5.97%-6.22%+228.95%+454.22% 38.14B
+6.53%+8.02%+16.40%+53.41% 33.24B
-0.90%-10.49%+37.09%-3.70% 25.2B
-1.07%+2.33%+19.43%+9.98% 22.5B
Average -1.66%-0.35%+45.52%+94.32% 41.37B
Weighted average by Cap. -2.20%-0.50%+44.25%+96.53%

Financials

2026 *2027 *
Net sales 325K 434K 385K 357K 613K 41.15M 623K 4.29M 1.68M 21.47M 1.63M 1.59M 68.45M 751K 1M 890K 825K 1.42M 95.03M 1.44M 9.92M 3.89M 49.59M 3.76M 3.68M 158M
Net income -42.18M -56.27M -50.02M -46.36M -79.6M -5.34B -80.87M -557M -218M -2.79B -211M -207M -8.88B -64.3M -85.78M -76.25M -70.67M -121M -8.14B -123M -849M -333M -4.25B -322M -315M -13.54B
Net Debt -133M -178M -158M -146M -251M -16.85B -255M -1.76B -689M -8.79B -666M -652M -28.03B -174M -232M -206M -191M -328M -22.04B -334M -2.3B -902M -11.5B -871M -853M -36.66B
Logo Silence Therapeutics plc
Silence Therapeutics plc is a global clinical-stage biotechnology company engaged in transforming people’s lives by silencing diseases through precision-engineered medicines created with proprietary siRNA (short interfering RNA) technology. The Company leverages its mRNAi GOLD platform to create siRNAs designed to precisely target and silence disease-associated genes in the liver. The Company focuses on areas of high unmet medical need with programs advancing cardiovascular disease, hematology and rare diseases. Divesiran (SLN124) is its wholly owned siRNA product candidate designed to inhibit TMPRSS6 expression in the liver. Zerlasiran is a siRNA molecule designed for the treatment of cardiovascular disease associated with elevated Lp(a), a lipoprotein in the blood. In addition to its wholly owned clinical pipeline, it has a third siRNA product candidate from its mRNAi GOLD platform in Phase I development in an undisclosed indication through its collaboration with AstraZeneca.
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MarketScreener Ratings - Silence Therapeutics plc