Valuation: Silence Therapeutics plc

Market Cap 434M 573M 512M 478M 816M 55.51B 824M 5.73B 2.24B 28.21B 2.15B 2.11B 90.72B P/E 2026 *
-17.9x
P/E 2027 * -14.4x
Enterprise Value 301M 397M 355M 331M 566M 38.48B 571M 3.97B 1.55B 19.55B 1.49B 1.46B 62.89B EV / Sales 2026 *
932x
EV / Sales 2027 * 346x
Free-Float
69.35%
Yield 2026 *
-
Yield 2027 * -
Manager TitleAgeSince
Chief Executive Officer 72 2025-11-30
Director of Finance/CFO 54 2022-01-31
Chief Tech/Sci/R&D Officer - 2020-12-31
Director TitleAgeSince
Director/Board Member 63 2018-06-20
Chairman 72 2003-12-31
Director/Board Member 65 2025-05-04
Change 5-day change 1-year change 3-year change Capi.($)
-3.19%-3.19%+44.60%+87.98% 74.68B
-15.86%-16.16%+2.68%+50.90% 58.7B
-2.39%-2.05%+4.29%+31.33% 48.36B
-6.35%-8.63%+293.39%+651.28% 43.05B
+0.30%-0.71%+29.05%+30.33% 42.48B
-3.82%-2.41%-0.27%+101.36% 41.39B
-2.13%+1.07%+7.51%+50.31% 31.29B
-3.35%-4.95%-13.38%-17.22% 23.93B
-1.24%-7.47%-37.90%+311.13% 22.22B
Average -4.23%-4.56%+36.66%+144.16% 42.9B
Weighted average by Cap. -4.86%-4.30%+43.05%+136.42%

Financials

2026 *2027 *
Net sales 322K 426K 380K 355K 607K 41.27M 613K 4.26M 1.67M 20.97M 1.6M 1.57M 67.44M 751K 992K 886K 826K 1.41M 96.05M 1.43M 9.92M 3.88M 48.81M 3.72M 3.64M 157M
Net income -42.14M -55.68M -49.72M -46.39M -79.29M -5.39B -80.06M -557M -218M -2.74B -209M -205M -8.81B -71.01M -93.84M -83.8M -78.17M -134M -9.09B -135M -939M -367M -4.62B -352M -345M -14.85B
Net Debt -133M -176M -157M -147M -250M -17.03B -253M -1.76B -688M -8.66B -660M -646M -27.84B -174M -230M -205M -192M -328M -22.27B -331M -2.3B -900M -11.32B -863M -845M -36.4B
Logo Silence Therapeutics plc
Silence Therapeutics plc is a global clinical-stage biotechnology company engaged in transforming people’s lives by silencing diseases through precision-engineered medicines created with proprietary siRNA (short interfering RNA) technology. The Company leverages its mRNAi GOLD platform to create siRNAs designed to precisely target and silence disease-associated genes in the liver. The Company focuses on areas of high unmet medical need with programs advancing cardiovascular disease, hematology and rare diseases. Divesiran (SLN124) is its wholly owned siRNA product candidate designed to inhibit TMPRSS6 expression in the liver. Zerlasiran is a siRNA molecule designed for the treatment of cardiovascular disease associated with elevated Lp(a), a lipoprotein in the blood. In addition to its wholly owned clinical pipeline, it has a third siRNA product candidate from its mRNAi GOLD platform in Phase I development in an undisclosed indication through its collaboration with AstraZeneca.
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ESG MSCI
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Ratings Surperformance© - Silence Therapeutics plc