Valuation: Silence Therapeutics plc

Market Cap 604M 823M 705M 661M 1.14B 78.47B 1.15B 7.8B 3.03B 39.59B 3.09B 3.02B 131B P/E 2026 *
-20.2x
P/E 2027 * -16.8x
Enterprise Value 471M 642M 550M 515M 888M 61.17B 897M 6.08B 2.37B 30.86B 2.41B 2.36B 102B EV / Sales 2026 *
1,449x
EV / Sales 2027 * 572x
Free-Float
69.35%
Yield 2026 *
-
Yield 2027 * -

Last Transcript: Silence Therapeutics plc

Manager TitleAgeSince
Chief Executive Officer 72 2025-11-30
Director of Finance/CFO 54 2022-01-31
Chief Tech/Sci/R&D Officer - 2020-12-31
Director TitleAgeSince
Director/Board Member 63 2018-06-20
Chairman 72 2003-12-31
Director/Board Member 65 2025-05-04
Change 5-day change 1-year change 3-year change Capi.($)
+1.02%+4.95%+3.67%+25.46% 51.21B
-0.09%-2.14%+492.60%+537.84% 45.35B
-0.32%+8.08%+37.97%+18.45% 42.84B
+1.18%+1.96%+21.95%+89.69% 42.29B
-2.27%-5.67%+14.55%+50.34% 32.15B
-0.96%+4.03%+31.55%+136.34% 17.31B
+0.41%+1.66% - - 16.55B
+1.12%+6.35%+11.00%+32.62% 14.84B
-0.31%+6.61%+81.37%+48.53% 14.25B
Average -0.04%+2.94%+86.83%+117.41% 30.75B
Weighted average by Cap. +0.03%+2.86%+105.36%+136.15%

Financials

2026 *2027 *
Net sales 325K 443K 379K 356K 613K 42.21M 619K 4.19M 1.63M 21.3M 1.66M 1.63M 70.53M 751K 1.02M 877K 822K 1.42M 97.56M 1.43M 9.69M 3.77M 49.22M 3.84M 3.76M 163M
Net income -41.45M -56.51M -48.43M -45.38M -78.22M -5.39B -79M -535M -208M -2.72B -212M -208M -9B -66.28M -90.37M -77.44M -72.56M -125M -8.62B -126M -856M -333M -4.35B -339M -332M -14.4B
Net Debt -133M -181M -155M -146M -251M -17.3B -254M -1.72B -669M -8.73B -681M -667M -28.91B -174M -237M -203M -191M -328M -22.62B -332M -2.25B -875M -11.41B -891M -872M -37.8B
Logo Silence Therapeutics plc
Silence Therapeutics plc is a global clinical-stage biotechnology company engaged in transforming people’s lives by silencing diseases through precision-engineered medicines created with proprietary siRNA (short interfering RNA) technology. The Company leverages its mRNAi GOLD platform to create siRNAs designed to precisely target and silence disease-associated genes in the liver. The Company focuses on areas of high unmet medical need with programs advancing cardiovascular disease, hematology and rare diseases. Divesiran (SLN124) is its wholly owned siRNA product candidate designed to inhibit TMPRSS6 expression in the liver. Zerlasiran is a siRNA molecule designed for the treatment of cardiovascular disease associated with elevated Lp(a), a lipoprotein in the blood. In addition to its wholly owned clinical pipeline, it has a third siRNA product candidate from its mRNAi GOLD platform in Phase I development in an undisclosed indication through its collaboration with AstraZeneca.
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