Valuation: Silence Therapeutics plc

Market Cap 373M 496M 435M 401M 704M 47.15B 719M 4.82B 1.87B 23.14B 1.86B 1.82B 80.55B P/E 2026 *
-17.6x
P/E 2027 * -15.6x
Enterprise Value 227M 301M 265M 244M 428M 28.66B 437M 2.93B 1.14B 14.07B 1.13B 1.11B 48.97B EV / Sales 2026 *
91x
EV / Sales 2027 * 36.1x
Free-Float
69.36%
Yield 2026 *
-
Yield 2027 * -
1 day-0.45%
1 month+107.55%
3 months+10.00%
6 months+10.00%
Current year+10.00%
1 month 1.8
Extreme 1.8
2.21
Current year 1.06
Extreme 1.06
2.63
1 year 1.06
Extreme 1.06
2.63
3 years 0.5
Extreme 0.4986
14.75
5 years 0.5
Extreme 0.4986
46.5
10 years 0.5
Extreme 0.4986
46.5
Manager TitleAgeSince
Chief Executive Officer 72 2025-12-13
Director of Finance/CFO 54 2022-02-20
Chief Tech/Sci/R&D Officer - 2020-12-31
Director TitleAgeSince
Director/Board Member 63 2018-06-20
Chairman 72 2019-11-30
Director/Board Member 54 2025-12-17
Change 5-day change 1-year change 3-year change Capi.($)
-0.45%-.--% - - 496M
+0.04%+4.62%+0.57%+6.16% 48.62B
+0.12%+10.45%+408.29%+600.97% 39.86B
+5.17%+9.47%+24.96%-9.60% 33.91B
+2.02%+4.91%+18.59%+63.06% 32.32B
+0.69%+1.04%+14.23%+30.86% 24.73B
+0.40%+12.51% - - 16.63B
+2.64%+6.00%+69.30%+126.33% 15.52B
+0.06%+0.32%+12.92%+17.62% 13.63B
+0.77%+10.67%+17.58%-30.04% 13.41B
Average +1.15%+7.05%+70.81%+100.67% 26.52B
Weighted average by Cap. +1.35%+7.14%+88.24%+128.51%

Financials

2026 *2027 *
Net sales 2.5M 3.31M 2.91M 2.68M 4.71M 315M 4.8M 32.21M 12.48M 155M 12.44M 12.17M 538M 3.44M 4.57M 4.01M 3.69M 6.49M 434M 6.62M 44.41M 17.21M 213M 17.16M 16.78M 742M
Net income -50.34M -66.85M -58.69M -54.02M -94.94M -6.36B -96.87M -650M -252M -3.12B -251M -246M -10.86B -84.67M -112M -98.71M -90.86M -160M -10.69B -163M -1.09B -423M -5.25B -422M -413M -18.26B
Net Debt -146M -194M -171M -157M -276M -18.49B -282M -1.89B -732M -9.07B -730M -714M -31.58B -249M -331M -291M -268M -470M -31.49B -480M -3.22B -1.25B -15.46B -1.24B -1.22B -53.79B
Logo Silence Therapeutics plc
Silence Therapeutics plc is a global clinical-stage biotechnology company engaged in transforming people’s lives by silencing diseases through precision-engineered medicines created with proprietary siRNA (short interfering RNA) technology. The Company leverages its mRNAi GOLD platform to create siRNAs designed to precisely target and silence disease-associated genes in the liver. The Company focuses on areas of high unmet medical need with programs advancing cardiovascular disease, hematology and rare diseases. Divesiran (SLN124) is its wholly owned siRNA product candidate designed to inhibit TMPRSS6 expression in the liver. Zerlasiran is a siRNA molecule designed for the treatment of cardiovascular disease associated with elevated Lp(a), a lipoprotein in the blood. In addition to its wholly owned clinical pipeline, it has a third siRNA product candidate from its mRNAi GOLD platform in Phase I development in an undisclosed indication through its collaboration with AstraZeneca.
Employees
88
Date Price Change Volume
Trader
Investor
-
Global
-
Quality
-
ESG MSCI
-
Sell
Consensus
Buy
Mean consensus
BUY
Number of Analysts
7
Last Close Price
10.50USD
Average target price
29.17USD
Spread / Average Target
+177.78%

Quarterly revenue - Rate of surprise