Valuation : Silence Therapeutics plc

Market Cap 650M 880M 757M 712M 1.22B 83.22B 1.22B 8.44B 3.26B 42.61B 3.3B 3.23B 136B P/E 2026 *
-21.6x
P/E 2027 * -17.9x
Enterprise Value 517M 700M 602M 566M 966M 66.17B 969M 6.71B 2.59B 33.88B 2.63B 2.57B 108B EV / Sales 2026 *
1,591x
EV / Sales 2027 * 634x
Free-Float
69.35%
Yield 2026 *
-
Yield 2027 * -

Last Transcript : Silence Therapeutics plc

1 day-1.35%
1 week+7.83%
Current month+7.83%
1 month+22.09%
3 months+136.47%
6 months+134.19%
Current year+139.97%
1 week 14.1
Extreme 14.1
15.28
1 month 13.01
Extreme 13.01
17.58
Current year 4.19
Extreme 4.19
17.58
1 year 4.19
Extreme 4.19
17.58
3 years 1.97
Extreme 1.97
27.72
5 years 1.97
Extreme 1.97
27.72
10 years 1.97
Extreme 1.97
35
Manager TitleAgeSince
Chief Executive Officer 72 2025-11-30
Director of Finance/CFO 54 2022-01-31
Chief Tech/Sci/R&D Officer - 2020-12-31
Director TitleAgeSince
Director/Board Member 63 2018-06-20
Chairman 72 2003-12-31
Director/Board Member 65 2025-05-04
Date Insider Type Main position Quantity % Market Cap. Importance
7/6/26 Sell 865,112 0.6105%
1/2/26 Free

Chief Financial Officer

375,000 0.2646%
1/2/26 Free

Director

90,000 0.0635%
Change 5-day change 1-year change 3-year change Capi.($)
-1.35%+7.83%+156.41%+71.65% 878M
-1.16%-2.77%-2.91%+13.85% 48.93B
-0.40%+2.16%+418.57%+554.47% 45.01B
-1.42%+2.52%+42.67%+22.27% 44.07B
-1.22%-0.37%+4.82%+84.42% 40.73B
-0.96%-1.38%+15.75%+45.91% 33.52B
-0.21%+2.86% - - 17.77B
-0.35%-0.45%+21.42%+117.63% 16.5B
-1.54%-1.30%+12.16%+31.14% 14.67B
-1.65%+0.09%+75.93%+41.15% 13.77B
Average -1.03%+1.12%+82.76%+109.17% 27.59B
Weighted average by Cap. -1.00%-0.02%+89.19%+134.15%

Financials

2026 *2027 *
Net sales 325K 440K 378K 356K 607K 41.59M 609K 4.22M 1.63M 21.3M 1.65M 1.62M 67.85M 751K 1.02M 874K 822K 1.4M 96.13M 1.41M 9.75M 3.77M 49.23M 3.82M 3.73M 157M
Net income -41.45M -56.14M -48.28M -45.41M -77.52M -5.31B -77.77M -538M -208M -2.72B -211M -206M -8.66B -66.28M -89.77M -77.2M -72.61M -124M -8.49B -124M -861M -333M -4.35B -337M -330M -13.85B
Net Debt -133M -180M -155M -146M -249M -17.05B -250M -1.73B -668M -8.73B -677M -662M -27.81B -174M -236M -203M -191M -325M -22.29B -327M -2.26B -874M -11.42B -885M -866M -36.36B
Logo Silence Therapeutics plc
Silence Therapeutics plc is a global clinical-stage biotechnology company engaged in transforming people’s lives by silencing diseases through precision-engineered medicines created with proprietary siRNA (short interfering RNA) technology. The Company leverages its mRNAi GOLD platform to create siRNAs designed to precisely target and silence disease-associated genes in the liver. The Company focuses on areas of high unmet medical need with programs advancing cardiovascular disease, hematology and rare diseases. Divesiran (SLN124) is its wholly owned siRNA product candidate designed to inhibit TMPRSS6 expression in the liver. Zerlasiran is a siRNA molecule designed for the treatment of cardiovascular disease associated with elevated Lp(a), a lipoprotein in the blood. In addition to its wholly owned clinical pipeline, it has a third siRNA product candidate from its mRNAi GOLD platform in Phase I development in an undisclosed indication through its collaboration with AstraZeneca.
Employees
88
Date Price Change Volume
26-09-04 US$14.59 -1.35% 611,151
26-09-03 US$14.79 0.00% 572,406
26-09-02 US$14.79 +0.34% 634,202
26-09-01 US$14.74 +8.94% 1,134,889
Trader
Investor
-
Global
-
Quality
-
ESG MSCI
-
Sell
Consensus
Buy
Mean consensus
BUY
Number of Analysts
7
Last Close Price
14.59USD
Average target price
33.00USD
Spread / Average Target
+126.18%

Quarterly revenue - Rate of surprise

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