Valuation: Silence Therapeutics plc

Market Cap 462M 611M 544M 507M 871M 58.79B 876M 6.12B 2.38B 29.99B 2.29B 2.24B 96.41B P/E 2026 *
-19.1x
P/E 2027 * -15.3x
Enterprise Value 329M 435M 387M 361M 620M 41.84B 623M 4.36B 1.7B 21.34B 1.63B 1.6B 68.62B EV / Sales 2026 *
1,019x
EV / Sales 2027 * 383x
Free-Float
69.35%
Yield 2026 *
-
Yield 2027 * -
3 months+166.67%
6 months+100.00%
Current year+100.00%
1 month 4
Extreme 4
4
Current year 1.06
Extreme 1.06
5.99
1 year 1.06
Extreme 1.06
5.99
3 years 0.5
Extreme 0.4986
14.75
5 years 0.5
Extreme 0.4986
46.5
10 years 0.5
Extreme 0.4986
46.5
Manager TitleAgeSince
Chief Executive Officer 72 2025-11-30
Director of Finance/CFO 54 2022-01-31
Chief Tech/Sci/R&D Officer - 2020-12-31
Director TitleAgeSince
Director/Board Member 63 2018-06-20
Chairman 72 2003-12-31
Director/Board Member 65 2025-05-04
Change 5-day change 1-year change 3-year change Capi.($)
-.--%-.--% - - 641M
+4.16%+3.04%+49.37%+94.17% 74.16B
-0.37%-3.88%+19.75%+78.35% 57.39B
+1.63%+0.98%+3.83%+38.21% 47.64B
+0.50%+1.32%+344.62%+753.25% 44.29B
+3.05%-1.58%+28.78%+35.46% 42.5B
+1.00%+0.22%+5.17%+113.80% 40.71B
-0.54%+2.93%+9.31%+54.06% 30.97B
+1.56%+4.53%+31.34%+26.92% 28.53B
+0.76%-0.89%-7.44%-11.43% 24.34B
Average +1.18%-0.59%+53.86%+131.42% 43.39B
Weighted average by Cap. +1.54%-0.84%+58.06%+140.75%

Financials

2026 *2027 *
Net sales 322K 426K 380K 354K 608K 41.05M 612K 4.28M 1.66M 20.94M 1.6M 1.57M 67.32M 751K 992K 884K 824K 1.41M 95.55M 1.42M 9.95M 3.87M 48.74M 3.72M 3.64M 157M
Net income -42.14M -55.71M -49.63M -46.29M -79.44M -5.36B -79.93M -559M -217M -2.74B -209M -205M -8.8B -71.01M -93.89M -83.64M -78.01M -134M -9.04B -135M -942M -367M -4.61B -352M -345M -14.83B
Net Debt -133M -176M -157M -146M -251M -16.94B -252M -1.77B -687M -8.64B -660M -646M -27.79B -174M -230M -205M -191M -328M -22.16B -330M -2.31B -898M -11.3B -863M -845M -36.33B
Logo Silence Therapeutics plc
Silence Therapeutics plc is a global clinical-stage biotechnology company engaged in transforming people’s lives by silencing diseases through precision-engineered medicines created with proprietary siRNA (short interfering RNA) technology. The Company leverages its mRNAi GOLD platform to create siRNAs designed to precisely target and silence disease-associated genes in the liver. The Company focuses on areas of high unmet medical need with programs advancing cardiovascular disease, hematology and rare diseases. Divesiran (SLN124) is its wholly owned siRNA product candidate designed to inhibit TMPRSS6 expression in the liver. Zerlasiran is a siRNA molecule designed for the treatment of cardiovascular disease associated with elevated Lp(a), a lipoprotein in the blood. In addition to its wholly owned clinical pipeline, it has a third siRNA product candidate from its mRNAi GOLD platform in Phase I development in an undisclosed indication through its collaboration with AstraZeneca.
Employees
88
Date Price Change Volume
Trader
Investor
-
Global
-
Quality
-
ESG MSCI
-
Sell
Consensus
Buy
Mean consensus
BUY
Number of Analysts
7
Last Close Price
10.14USD
Average target price
33.00USD
Spread / Average Target
+225.44%

Quarterly revenue - Rate of surprise