Valuation: Spyre Therapeutics, Inc.

Market Cap 9.02B 8.08B 7.43B 6.74B 12.59B 857B 12.83B 88.65B 35.59B 451B 33.87B 33.15B 1,421B P/E 2026 *
-33.5x
P/E 2027 * -26.7x
Enterprise Value 8.46B 7.57B 6.97B 6.31B 11.8B 803B 12.02B 83.06B 33.34B 422B 31.73B 31.06B 1,332B EV / Sales 2026 *
-
EV / Sales 2027 * -
Free-Float
93.73%
Yield 2026 *
-
Yield 2027 * -
1 day-2.43%
1 week+6.90%
Current month+8.46%
1 month+8.46%
3 months-4.87%
6 months+29.70%
Current year+194.75%
1 week 90.35
Extreme 90.35
100.42
1 month 76.87
Extreme 76.87
100.42
Current year 28
Extreme 28
110.18
1 year 21.14
Extreme 21.145
110.18
3 years 8.43
Extreme 8.43
110.18
5 years 2.66
Extreme 2.66
198.5
10 years 2.66
Extreme 2.66
300
Manager TitleAgeSince
Chief Executive Officer 36 2023-11-26
Director of Finance/CFO 49 2023-08-31
Chief Tech/Sci/R&D Officer - 2023-11-26
Director TitleAgeSince
Director/Board Member 36 2023-11-26
Director/Board Member 40 2023-06-21
Director/Board Member 36 2023-06-21
Date Insider Type Main position Quantity % Market Cap. Importance
10/1/26 Exercice

General Counsel

86,799 0.0984%
10/1/26 Exercice

Chief Financial Officer

22,500 0.0255%
10/1/26 Sell

Chief Executive Officer

-15,000 0.0170%
Change 5-day change 1-year change 3-year change Capi.($)
-2.43%+6.90%+298.02%+726.71% 9.02B
-0.62%-1.87%+46.31%+56.99% 63.77B
+0.35%+3.20%+14.92%+84.55% 56.37B
+0.53%+1.96%+15.37%+106.81% 54.62B
-2.81%-4.31%+23.50%+50.90% 44.06B
-0.33%-1.93%+20.15%+98.45% 42.11B
+0.55%+2.31%+224.97%+942.56% 41B
+3.27%+47.96%+112.67%+96.48% 34.92B
+1.22%-1.44%+14.89%+47.15% 32.82B
+0.89%+20.55%-42.03%+373.03% 24.7B
Average +0.06%+7.48%+72.88%+258.36% 40.34B
Weighted average by Cap. +0.12%+5.48%+54.08%+198.22%

Financials

2026 *2027 *
Net sales - -
Net income -258M -231M -212M -192M -360M -24.47B -366M -2.53B -1.02B -12.87B -967M -947M -40.6B -340M -304M -280M -254M -474M -32.28B -483M -3.34B -1.34B -16.98B -1.28B -1.25B -53.55B
Net Debt -569M -509M -468M -424M -793M -53.99B -808M -5.59B -2.24B -28.4B -2.13B -2.09B -89.56B -610M -546M -503M -455M -851M -57.92B -867M -5.99B -2.41B -30.47B -2.29B -2.24B -96.09B
Projected Income Statement - Annual - Spyre Therapeutics, Inc.
Logo Spyre Therapeutics, Inc.
Spyre Therapeutics, Inc. is a clinical-stage biotechnology company, specializing in long-acting antibodies and antibody combinations for inflammatory bowel disease (IBD) and rheumatic diseases. The Company's pipeline includes investigational extended half-life antibodies targeting a4b7, TL1A, and IL-23. It is advancing a pipeline of monoclonal antibodies (mAbs) for the treatment of IBD and other immune-mediated diseases. The Company's pipeline includes its SKYLINE Phase II platform trial evaluating SPY001, SPY002, SPY003, and pairwise combinations thereof in subjects with moderately to severely active UC and its SKYWAY basket trial evaluating SPY072 in three rheumatic diseases: rheumatoid arthritis (RA), psoriatic arthritis (PsA), and axial spondyloarthritis (axSpA). SPY001 is a highly potent, highly selective, and humanized monoclonal immunoglobulin G1 investigational antibody designed to bind selectively to the a4b7 integrin being developed for the treatment of IBD (UC and CD).
Employees
125
Date Price Change Volume
26-10-30 US$96.56 -2.43% 661,126
26-10-29 US$98.96 -0.79% 567,636
26-10-28 US$99.75 +0.71% 724,549
26-10-27 US$99.05 +6.60% 944,931
26-10-26 US$92.91 +2.86% 637,181
Trader
Investor
-
Global
-
Quality
-
ESG MSCI
BB
MarketScreener Ratings - Spyre Therapeutics, Inc.
Sell
Consensus
Buy
Mean consensus
BUY
Number of Analysts
18
Last Close Price
96.56USD
Average target price
122.33USD
Spread / Average Target
+26.69%

Quarterly revenue - Rate of surprise

Rate of surprise - Net sales - Quarterly - Spyre Therapeutics, Inc.
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