Valuation: Septerna, Inc.

Market Cap 1.76B 1.55B 1.46B 1.33B 2.49B 169B 2.51B 17.48B 6.77B 86.32B 6.62B 6.48B 277B P/E 2026 *
-28x
P/E 2027 * -16.6x
Enterprise Value 1.38B 1.21B 1.15B 1.04B 1.96B 133B 1.97B 13.72B 5.31B 67.72B 5.19B 5.08B 218B EV / Sales 2026 *
14.4x
EV / Sales 2027 * 17.5x
Free-Float
99.08%
Yield 2026 *
-
Yield 2027 * -
1 day-0.94%
1 week-2.38%
Current month-1.00%
1 month-6.16%
3 months+1.15%
6 months+52.67%
Current year+35.47%
1 week 36.98
Extreme 36.98
41.09
1 month 36.01
Extreme 36.01
41.09
Current year 22.78
Extreme 22.78
51.1
1 year 17.33
Extreme 17.33
51.1
3 years 4.17
Extreme 4.17
51.1
5 years 4.17
Extreme 4.17
51.1
10 years 4.17
Extreme 4.17
51.1
Manager TitleAgeSince
Chief Executive Officer 60 2021-10-31
Director of Finance/CFO 55 2025-01-05
President 58 2025-07-31
Director TitleAgeSince
Director/Board Member 60 2021-10-31
Chairman 50 2021-10-31
Director/Board Member 41 2021-10-31
Date Insider Type Main position Quantity % Market Cap. Importance
9/8/26 Free

Chief Technology Officer

275,000 0.5892%
9/1/26 Exercice

Executive/Senior Manager

9,999 0.0214%
8/12/26
RA Capital Management LP
SellCompany -1,493,000 3.3122%
Change 5-day change 1-year change 3-year change Capi.($)
-0.94%-2.38%+116.45% - 1.76B
-0.14%+4.33%+9.00%+31.64% 47.97B
-1.69%+1.48%+50.57%+34.53% 44.5B
+2.56%+7.34%+366.69%+608.26% 43.93B
+0.24%+2.85%+10.67%+94.47% 41.03B
-0.62%-1.11%+4.65%+48.91% 29.85B
-0.28%+1.07%+24.58%+155.58% 17.27B
+3.37%+9.21%+8.32% - 15.34B
-0.46%+1.20%+26.90%+42.21% 15.3B
-2.21%-4.70% - - 14.82B
Average -0.02%+1.88%+68.65%+145.08% 27.18B
Weighted average by Cap. +0.10%+2.83%+79.92%+160.28%

Financials

2026 *2027 *
Net sales 96.09M 84.32M 79.63M 72.57M 136M 9.21B 137M 953M 369M 4.7B 361M 353M 15.12B 73.66M 64.64M 61.05M 55.63M 104M 7.06B 105M 731M 283M 3.61B 277M 271M 11.59B
Net income -61.3M -53.79M -50.8M -46.29M -86.66M -5.87B -87.28M -608M -235M -3B -230M -225M -9.65B -115M -101M -95.37M -86.92M -163M -11.03B -164M -1.14B -442M -5.63B -432M -423M -18.11B
Net Debt -380M -333M -315M -287M -537M -36.42B -541M -3.77B -1.46B -18.61B -1.43B -1.4B -59.8B -476M -418M -395M -360M -673M -45.65B -678M -4.72B -1.83B -23.32B -1.79B -1.75B -74.95B
Logo Septerna, Inc.
Septerna, Inc. is a clinical-stage biotechnology company. The Company is developing G protein-coupled receptor (GPCR) oral small-molecule drug discovery powered by its proprietary Native Complex Platform. It is advancing programs in endocrinology, immunology and inflammation, metabolic diseases and additional therapeutic areas, both independently and with partners. The Company's Native Complex Platform is designed to enable it to target certain GPCRs for the first time, uncover novel binding pockets for validated receptors, and pursue a wide spectrum of pharmacologies, including agonists, antagonists, and allosteric modulators, to achieve desired therapeutic effects. It is advancing a deep portfolio of oral small molecule GPCR-targeted programs with novel mechanistic approaches to treat diseases across multiple therapeutic areas for patients with significant unmet needs. It is focused on therapeutic areas, such as neurology, women’s health, cardiovascular, and respiratory disease.
Employees
123
Date Price Change Volume
26-09-25 US$37.77 -0.94% 344,295
26-09-24 US$38.13 -0.83% 293,140
26-09-23 US$38.45 -4.78% 509,719
26-09-22 US$40.38 +4.77% 412,055
26-09-21 US$38.54 -0.39% 252,437
Trader
Investor
-
Global
-
Quality
-
ESG MSCI
BB
Sell
Consensus
Buy
Mean consensus
BUY
Number of Analysts
10
Last Close Price
37.77USD
Average target price
54.22USD
Spread / Average Target
+43.56%

Quarterly revenue - Rate of surprise

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