Valuation: Centessa Pharmaceuticals plc

Market Cap 6.27B 5.48B 5.05B 4.66B 8.78B 603B 8.97B 60.4B 23.76B 296B 23.53B 23.02B 1,017B P/E 2024
-8.13x
P/E 2025 -17.2x
Enterprise Value 6.09B 5.32B 4.91B 4.53B 8.53B 587B 8.72B 58.7B 23.09B 287B 22.87B 22.37B 989B EV / Sales 2024
-
EV / Sales 2025 231,810,355x
Free-Float
78.43%
Yield 2024 *
-
Yield 2025 -
1 day+0.80%
1 month+1.20%
3 months+2.12%
6 months+82.43%
Current year+61.94%
1 month 39.98
Extreme 39.98
40.56
Current year 21.5
Extreme 21.5
40.56
1 year 15.01
Extreme 15.01
40.56
3 years 5.15
Extreme 5.15
40.56
5 years 2.88
Extreme 2.885
40.56
10 years 2.88
Extreme 2.885
40.56
Manager TitleAgeSince
Chief Tech/Sci/R&D Officer - 2024-09-30
Chief Tech/Sci/R&D Officer 55 2023-02-28
Chief Administrative Officer 58 2021-03-31
Director TitleAgeSince
Director/Board Member - 2026-06-23
Director/Board Member - 2026-06-23
Date Insider Type Main position Quantity % Market Cap.
6/24/26 Issuer sale

Director

-392,474 0.2537%
6/24/26
Medicxi Ventures (Jersey) Ltd.
Issuer saleCompany -19,963,157 12.9020%
6/24/26 Issuer sale

Head of Human Resources

-486,345 0.3143%
Change 5-day change 1-year change 3-year change Capi.($)
+0.80%-.--%+158.13%+426.66% 6.27B
-1.29%-3.11%-0.35%+3.09% 49.18B
+3.90%-0.39%+386.06%+593.85% 39.58B
-1.70%+4.46%+5.93%+60.25% 34.69B
-2.01%-0.76%+28.41%-8.01% 34.42B
+0.06%+0.34%+2.38%+34.38% 27.11B
+0.46%-3.49% - - 16.21B
-0.04%-0.09%+72.42%+115.55% 15.36B
+1.12%+1.91%+14.54%+19.16% 14.05B
0.00%+1.36%+18.43%-30.79% 13.02B
Average +0.13%+0.21%+76.22%+134.90% 24.99B
Weighted average by Cap. -0.03%-0.13%+81.55%+131.45%

Financials

2024 2025
Net sales - 15 13.11 12.1 11.15 21.02 1.44K 21.48 144.58 56.87 707.47 56.33 55.1 2.44K
Net income -236M -206M -190M -175M -330M -22.7B -338M -2.27B -894M -11.12B -885M -866M -38.28B -198M -173M -159M -147M -277M -19.02B -283M -1.9B -749M -9.32B -742M -726M -32.07B
Net Debt -364M -318M -294M -271M -510M -35.09B -522M -3.51B -1.38B -17.18B -1.37B -1.34B -59.16B -176M -154M -142M -131M -247M -16.97B -252M -1.7B -668M -8.31B -662M -647M -28.61B
Logo Centessa Pharmaceuticals plc
Centessa Pharmaceuticals plc is a clinical-stage pharmaceutical company. The Company is developing a new class of potential therapies within its orexin receptor 2 (OX2R) agonist program for the treatment of excessive daytime sleepiness (EDS), impaired attention, cognitive deficits, fatigue and other symptoms across neurological, neurodegenerative and neuropsychiatric disorders. It also has an early-stage immuno-oncology program focused on its LockBody technology platform. Its OX2R agonist pipeline includes ORX750, its advanced OX2R agonist development candidate, and ORX142, ORX489 and OX2R agonists in preclinical development. Its ORX750, an investigational, orally administered, highly potent and selective OX2R agonist, is in a Phase IIa study of participants with narcolepsy type 1 (NT1), NT2 and idiopathic hypersomnia (IH). ORX142 is the second OX2R agonist development candidate being advanced for the treatment of neurological and neurodegenerative disorders and other symptoms.
Employees
129
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