Valuation : Centessa Pharmaceuticals plc

Market Cap 6.27B 5.39B 5.08B 4.63B 8.66B 596B 8.69B 60.18B 23.26B 304B 23.53B 23.02B 962B P/E 2024
-8.13x
P/E 2025 -17.2x
Enterprise Value 6.09B 5.24B 4.93B 4.5B 8.41B 580B 8.45B 58.49B 22.6B 295B 22.87B 22.37B 935B EV / Sales 2024
-
EV / Sales 2025 231,810,355x
Free-Float
78.43%
Yield 2024 *
-
Yield 2025 -
1 day+0.80%
3 months+1.86%
6 months+55.23%
Current year+61.94%
Current year 21.5
Extreme 21.5
40.56
1 year 17.05
Extreme 17.05
40.56
3 years 5.15
Extreme 5.15
40.56
5 years 2.88
Extreme 2.885
40.56
10 years 2.88
Extreme 2.885
40.56
Manager TitleAgeSince
Chief Tech/Sci/R&D Officer - 2024-09-30
Chief Tech/Sci/R&D Officer 55 2023-02-28
Chief Administrative Officer 58 2021-03-31
Director TitleAgeSince
Director/Board Member - 2026-06-23
Director/Board Member - 2026-06-23
Date Insider Type Main position Quantity % Market Cap. Importance
6/24/26
Medicxi Ventures (Jersey) Ltd.
SellCompany -19,963,157 12.9020%
5/1/26 Tax

Chief Executive Officer

-604 0.0004%
3/26/26 Exercice

Executive/Senior Manager

71,994 0.0539%
Change 5-day change 1-year change 3-year change Capi.($)
+0.80%-.--%+94.24%+526.93% 6.27B
+0.78%-6.98%-2.73%+11.12% 46.38B
+0.17%-0.74%+407.28%+546.58% 44.51B
-0.86%-2.60%+35.51%+20.35% 42.3B
-0.14%-2.98%-0.04%+82.21% 39.91B
0.00%-1.72%+13.42%+42.33% 32.79B
-3.44%-2.43% - - 17.13B
-0.78%-1.13%+20.74%+116.26% 16.36B
+0.48%-3.76%+12.33%+30.49% 14.31B
-0.86%-4.60%+76.86%+39.36% 13.29B
Average -0.47%-2.41%+73.07%+157.29% 27.32B
Weighted average by Cap. -0.29%-2.93%+86.18%+142.67%

Financials

2024 2025
Net sales - 15 12.91 12.15 11.07 20.72 1.43K 20.8 144.04 55.67 727.16 56.32 55.1 2.3K
Net income -236M -203M -191M -174M -326M -22.43B -327M -2.26B -875M -11.43B -885M -866M -36.21B -198M -170M -160M -146M -273M -18.8B -274M -1.9B -733M -9.58B -742M -726M -30.34B
Net Debt -364M -314M -295M -269M -503M -34.67B -505M -3.5B -1.35B -17.66B -1.37B -1.34B -55.96B -176M -152M -143M -130M -243M -16.77B -244M -1.69B -654M -8.54B -662M -647M -27.06B
Logo Centessa Pharmaceuticals plc
Centessa Pharmaceuticals Limited, formerly Centessa Pharmaceuticals plc, is a clinical-stage pharmaceutical company, developing a new class of potential therapies within its orexin receptor 2 (OX2R) agonist program for the treatment of excessive daytime sleepiness, impaired attention, cognitive deficits, fatigue and other symptoms across neurological, neurodegenerative and neuropsychiatric disorders. It has an early-stage immuno-oncology program focused on its LockBody technology platform. The OX2R agonist pipeline includes ORX750, its advanced OX2R agonist development candidate, and ORX142, ORX489 and OX2R agonists in preclinical development. Its ORX750, an investigational, orally administered, highly potent and selective OX2R agonist, is in a Phase IIa study of participants with narcolepsy type 1, NT2 and idiopathic hypersomnia. ORX142 is the second OX2R agonist development candidate being advanced for the treatment of neurological and neurodegenerative disorders and other symptoms.
Employees
129
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