![Marcella Ruddy](data:image/svg+xml,<svg xmlns="http://www.w3.org/2000/svg" width="16" height="16" fill="%231b1b1b" class="bi bi-person-fill" viewBox="0 0 16 16"><path d="M3 14s-1 0-1-1 1-4 6-4 6 3 6 4-1 1-1 1zm5-6a3 3 0 1 0 0-6 3 3 0 0 0 0 6"/></svg>)
Marcella Ruddy
Director/Board Member at
UPSTREAM BIO, INC.
Net worth: 2 M $ as of 2026-05-30
Profile
Marcella Kuhlman Ruddy is currently Director at MKRuddy Consulting LLC, Independent Director at Upstream Bio, Inc. since 2023, Independent Non-Executive Director at Sionna Therapeutics, Inc. starting in 2025, and Chief Medical Officer at both Tectonic Operating Co., Inc. and Tectonic Therapeutic, Inc. since 2021.
Former roles include Non-Executive Director at Polarean Imaging Plc from 2022 to 2024, Head-Early Clinical Development at Merck & Co., Inc. from 2004 to 2014, Vice President-Clinical Development at Alnylam Pharmaceuticals, Inc. from 2015 to 2016, Vice President-Clinical Immunology at EMD Serono, Inc. in 2014, Chief Medical Officer at AVROBIO, Inc., and Head-Group Inflammation at Regeneron Pharmaceuticals, Inc. from 2016 to 2021.
Education includes undergraduate studies at Princeton University and graduate and doctorate degrees from Washington University in St. Louis.
Known holdings in public companies
| Company | Date | Number of shares | Valuation | Valuation date |
|---|---|---|---|---|
0.36% | 2026-05-03 | 67,682 ( 0.36% ) | 2 M $ | 2026-05-30 |
UPSTREAM BIO, INC. -.--% | 2026-06-08 | 0 ( -.--% ) | - $ | 2026-05-30 |
| 2026-06-16 | 0 ( -.--% ) | - $ | 2026-05-30 |
Marcella Ruddy active positions
| Companies | Position | Start |
|---|---|---|
| UPSTREAM BIO, INC. | Director/Board Member | 2022-12-31 |
| SIONNA THERAPEUTICS, INC. | Director/Board Member | 2025-01-07 |
Tectonic Therapeutic, Inc.
 Tectonic Therapeutic, Inc. Miscellaneous Commercial ServicesCommercial Services Operates biotechnology company that transforming the discovery of novel G-protein-coupled receptors targeted therapies | Chief Tech/Sci/R&D Officer | 2021-06-30 |
MKRuddy Consulting LLC | Director/Board Member | - |
Former positions of Marcella Ruddy
| Companies | Position | End |
|---|---|---|
| POLAREAN IMAGING PLC | Director/Board Member | 2024-07-23 |
| REGENERON PHARMACEUTICALS, INC. | Corporate Officer/Principal | 2021-05-31 |
| ALNYLAM PHARMACEUTICALS, INC. | Corporate Officer/Principal | 2016-05-31 |
EMD Serono, Inc.
 EMD Serono, Inc. Pharmaceuticals: MajorHealth Technology Develops recombinant prescription medicines | Corporate Officer/Principal | 2014-10-31 |
| MERCK & CO., INC. | Corporate Officer/Principal | 2014-05-31 |
Training of Marcella Ruddy
Experiences
Positions held
Active
Inactive
Listed companies
Private companies
Connections
84
1st degree connections
12
1st degree companies
Male
Female
Members of the board
Executives
Linked companies
| Private companies | 12 |
|---|---|
Merck & Co., Inc.
 Merck & Co., Inc. Pharmaceuticals: MajorHealth Technology Manufactures human and animal health pharmaceutical products & vaccines | Health Technology |
Regeneron Pharmaceuticals, Inc.
 Regeneron Pharmaceuticals, Inc. Pharmaceuticals: MajorHealth Technology Discovers, develops, manufactures and commercializes medicines for diseases | Health Technology |
Washington University in St. Louis
 Washington University in St. Louis Other Consumer ServicesConsumer Services Functions as a College/University | Consumer Services |
Alnylam Pharmaceuticals, Inc.
 Alnylam Pharmaceuticals, Inc. Pharmaceuticals: MajorHealth Technology Develops and commercializes therapeutics based on RNA interference | Health Technology |
Princeton University
 Princeton University Other Consumer ServicesConsumer Services Functions as a College/University | Consumer Services |
EMD Serono, Inc.
EMD Serono, Inc. Pharmaceuticals: MajorHealth Technology Develops recombinant prescription medicines | Health Technology |
AVROBIO, Inc.
 AVROBIO, Inc. BiotechnologyHealth Technology Develops potentially curative ex vivo lentiviral-based gene therapies to treat rare diseases in a single dose | Health Technology |
Polarean Imaging Plc
 Polarean Imaging Plc Medical SpecialtiesHealth Technology Designs, manufactures and sells noble gas polarizer devices & ancillary instruments | Health Technology |
Sionna Therapeutics, Inc.
 Sionna Therapeutics, Inc. BiotechnologyHealth Technology Develops therapies for CF and rare diseases | Health Technology |
Tectonic Therapeutic, Inc.
Tectonic Therapeutic, Inc. Miscellaneous Commercial ServicesCommercial Services Operates biotechnology company that transforming the discovery of novel G-protein-coupled receptors targeted therapies | Commercial Services |
Upstream Bio, Inc.
 Upstream Bio, Inc. BiotechnologyHealth Technology Engages in developing treatments for inflammatory diseases | Health Technology |
MKRuddy Consulting LLC |
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