Zivo Bioscience : January 2023 Investor Presentation

(Nasdaq: ZIVO)

Transformative

Opportunities in

Therapeutics &

Nutrition

January 2023

Disclaimer

SPECIAL NOTE REGARDING FORWARD-LOOKING STATEMENTS

Some of the statements contained in this presentation are forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. These statements involve known and unknown risks, uncertainties and other factors which may cause our or our industry's actual results, performance or achievements to be materially different from any future results, performance or achievements expressed or implied by the forward-looking statements. Forward-looking statements include, but are not limited to statements regarding:

• The Company's ability to raise the funds we need to continue our operations;
• The Company's goal to begin to generate revenues and become profitable;
• Regulation of our products;
• Market acceptance of our products and derivatives thereof;
• The results of current and future testing of our products;
• The anticipated performance and benefits of our product;
• The Company's ability to expand its intellectual property;
• The Company's ability to enter into strategic partnerships;
• The Company's ability to generate licensing fees; and
• The Company's financial condition or results of operations

In some cases, you can identify forward-looking statements by terms such as "may", "will", "should", "could", "would", "expects", "plans", "anticipates", "believes", "estimates", "projects", "predicts", "potential" and similar expressions intended to identify forward looking statements. These statements are only predictions and involve known and unknown risks, uncertainties, and other factors that may cause our actual results, levels of activity, performance, or achievements to be materially different from any future results, levels of activity, performance, or achievements expressed or implied by such forward-looking statements. Given these uncertainties, you should not place undue reliance on these forward- looking statements. Also, these forward-looking statements represent our estimates and assumptions only as of the date of this report. Except as otherwise required by law, we expressly disclaim any obligation or undertaking to release publicly any updates or revisions to any forward-looking statement contained in this presentation to reflect any change in our expectations or any change in events, conditions or circumstances on which any of our forward-looking statements are based. We qualify all of our forward-looking statements by these cautionary statements.

THE INFORMATION IN THIS PRESENTATION IS PROVIDED TO YOU SOLELY FOR INFORMATIONAL PURPOSES AND IS NOT AN OFFER TO BUY OR SELL, A SOLICITATION OF AN OFFER TO BUY OR SELL, ANY SECURITY OR INSTRUMENT OF THE COMPANY, OR TO PARTICIPATE IN ANY INVESTMENT ACTIVITY OR TRADING STRATEGY.

ZIVO Bioscience, Inc. | NASDAQ: ZIVO

Investment Overview

One Natural Source. Numerous Value-Driving Opportunities.

Developing novel therapeutic candidates and nutritional functional food ingredients to power immune health

Near-Term Revenue:

• Via out-licensing IP for a product candidate for the treatment of coccidiosis in poultry
• Commercializing an algae nutritional supplement for the human green powder and vegan protein markets

Long-term Valuation Multiplier:

• Published studies demonstrate an active therapeutics pipeline addressing billion-dollar opportunities in animal and human disease treatment through immune and other novel pathways
• Multi use nutritional ingredient in various foods for animals and humans

Robust and Versatile Products:

• Various commercial applications in animal feed, functional and medical foods, dietary supplements, nutraceuticals and pharmaceuticals

ZIVO Bioscience, Inc. | NASDAQ: ZIVO

• Patent-pendinguse as an immune modulating candidate which may establish a new class of therapeutic products
• Potentially numerous therapeutic applications across three global mega-markets: human, livestock, and companion animals.

Zivo Bioscience, Inc. - At a Glance

One Natural Source. Numerous Value-Driving Opportunities.

Therapeutics (biotech)

Nutrition (agtech)

• Isolation, identification and development of extracts, fractions, or molecules derived from proprietary algal polyculture
• For use in the treatment of disease or other health conditions in humans and animals.
• Protected by patents or trade secrets.
• Monetized through licensing, joint venturing, or other structures to leverage established product development, manufacturing and sales and distribution

capabilities.

ZIVO Bioscience, Inc. | NASDAQ: ZIVO

• Growth and distribution of Zivo's proprietary whole algal biomass for use as a food or food ingredient to take advantage of its unique nutritional characteristics.
• The identified components of our algae allow many potential structure-function claims for nutrition and overall health enhancement.
• Implementation of the nutritional strategy through ZIVOLife subsidiary.
• • This opens the door for specific investment for the growing of algae, product development, and sales and distribution of whole algae products.

Poultry Study Results

Significant Market Opportunity in Therapeutic Markets

Novel active compounds have broad applicability for treatment of disease Market Opportunity

Performed twenty poultry studies to evaluate the efficacy	$10 billion
in the treatment of coccidiosis
Validated efficacy and mechanism of action studies in	Worldwide annual cost of coccidiosis in poultry
poultry gut health:
 Minimized or eliminated negative effects of coccidiosis	$5.8 billion by 2027
on growth performance and digestive health	Worldwide animal antimicrobials market
 Reduced incidence of Campylobacter, Salmonella, E.
coli, and C. perfringens in digestive tracts	$753M in 2020  $1.1B by 2025
Currently being independently validated by a global
Global feed phytogenic market size growth
animal pharma company
Commercial Application	$14.6B in 2020  $23.9B by 2028
Therapeutic additive designed to be introduced in poultry feed or	Global animal growth promoters and performance
enhancers market size growth
drinking water - IP protected via global patent strategy
Potential as a replacement for antibiotics, ionophores, and other
chemical-based treatments
Joint development agreement and / or license negotiations upon
successful third-party validation
ZIVO Bioscience, Inc. | NASDAQ: ZIVO	5