Waters Corporation introduced BioResolve™ RP mAb Polyphenyl 450 angstrom 2.7 micron solid core Columns intended for the reversed-phase analysis of intact or sub-unit-digested monoclonal antibodies (mAbs) and antibody-drug conjugates (ADCs) using LC-UV and LC-MS. In addition to getting performance-driven columns, users of BioResolve brand columns will receive application-focused standards, templated methods, and an enhanced level of applications support to help ensure that they can consistently and reliably perform bioseparations. With the introduction of BioResolve RP mAb Polyphenyl Columns, Waters continues its commitment to the biopharmaceutical industry by meeting the needs of analytical scientists and lab managers across the discovery, development and manufacturing pipeline. The combination of the BioResolve RP mAb Polyphenyl Column 450 angstrom solid-core particle design and proprietary polyphenyl ligand bonding makes it especially well-suited for reversed phase separations of intact mAbs, IdeS generated fragments and similarly sized proteins. These columns establish a new industry standard for separation selectivity, efficiency, sample recovery and low injection-to-injection carryover even when operated at lower temperatures. The BioResolve RP mAb Polyphenyl 450 angstrom 2.7 micron Columns are available in lengths of 50, 100 or 150 millimeters and internal diameters of 2.1 or 4.6 millimeters for compatibility with UltraPerformance Liquid Chromatography ™ (UPLC™), Ultra-High Performance Liquid Chromatography (UHPLC) or High Performance Liquid Chromatography (HPLC) separations platforms thus facilitating easy method transfer between discovery, development and manufacturing/QC applications. In addition, the columns are shipped with the same reduced IdeS-digested NIST reference material that Waters uses to quality-test each batch of stationary phase. The new BioResolve RP mAb Polyphenyl Columns are now available worldwide from Waters.