Effective on December 17, 2020 Shoshana Shendelman, Ph.D. resigned from the Board of Director of 180 Life Sciences Corp. due to potential conflicts of interest which have arisen between her position on the Board of Directors and Ms. Shendelman's other endeavors. Additionally, effective on December 18, 2020, Prof. Richard W. Barker, MA, D.Phil, OBE, resigned from the Board of Directors of the company, because of other commitments that would not allow him to spend sufficient time on company matters. Neither Ms. Shendelman's, nor Mr. Barker's, resignations were in connection with a disagreement with the company on any matter relating to the company's operations, policies, or practices, and both former directors wished the company future success.