Stevia Corp. announced the filing of two additional provisional patent applications with the United States Patent and Trademark Office (USPTO) for the treatment of pain and cardiovascular disease. The two separate applications include a provisional patent application that contains a formulation of naproxen and cannabidiol (CBD) and another application that contains a formulation of aspirin and cannabidiol.

Stevia Corp. has now filed four provisional patent applications with the USPTO for four of the large selling generic pain killing medications worldwide in combination with CBD. All four provisional patent applications were filed with the assistance of an intellectual property attorney with extensive experience in the healthcare industry.

A provisional patent application is a legal document which establishes an early priority date for the benefit of claiming 'first to file' status against other companies or individuals that may want to file a patent with similar claims after the filing date of the provisional patent. Naproxen is a non-steroidal anti-inflammatory drug used to treat both pain and inflammation. Although the mechanism of action of NSAIDs such as naproxen are not completely understood, they are believed to work by inhibiting the synthesis of prostaglandins which are fat-like molecules that are involved in mediating inflammation, pain and fever.

It achieves this synthesis by inhibiting cyclooxygenase, an enzyme that is present in various tissues of the body. Aspirin is a painkiller and an anti-inflammatory agent with a long history of safe use. Aspirin is also frequently prescribed to individuals that have experienced an adverse cardiac event such as myocardial infarction.

Furthermore, aspirin is used for the prevention of cardiac disease. Aspirin works for pain care and inflammation by inhibiting the synthesis of prostaglandins, which are fat-like molecules that are involved in mediating inflammation, pain and fever. Aspirin also has an antiplatelet effect by inhibiting the production of thromboxane.

Under normal circumstances, thromboxane binds platelet molecules together to create a patch over a damaged section of a blood vessel. If and when the platelet patch becomes too large, it can restrict blood flow resulting in a heart attack or stroke. If atherosclerosis is present or an individual's family has a history of heart disease, a daily dose of aspirin may be prescribed after a heart attack or to prevent another heart attack.

In many cases, a daily dose of aspirin is prescribed for the prevention and management of signs of cardiovascular disease. Cannabidiol (CBD) is a cannabinoid that is present in most varieties of the cannabis sativa and cannabis indica plants. Cannabinoids are unique to the cannabis sativa and cannabis indica plants.

Unlike some of the other molecules found in varieties of the cannabis plant, it is non-psychoactive and it is not believed to have any addictive properties. It is also extremely well tolerated at high doses with little or no adverse side effects. Cannabidiol catapulted into a national story after being an important part of the 2013 CNN documentary 'Weed'.