Kintor Pharmaceutical Limited announced that the company has completed the enrollment of 180 patients for the Phase II clinical trial of its in-house developed first-in-class proteolysis targeting chimera (PROTAC) compound GT20029 in China for the treatment of male androgenetic alopecia (AGA). GT20029 was developed based on the in-house PROTAC platform and is the world's first topical PROTAC compound which has entered the Phase II clinical stage. The Phase II clinical trial is a multi-center, randomized, double-blind, placebo-controlled study designed to evaluate the efficacy and safety of GT20029 for treating male AGA patients in China, and to determine the recommended dosage for the Phase III clinical trial.

This trial involves a total of 12 clinical research centers in China, and Professor Yang Qinping from Fudan University Huashan Hospital is the leading principal investigator (leading PI). The primary endpoint of this trial is the change from baseline in non-vellus target area hair counts (TAHC) after 12 weeks of treatment in comparison to placebo. Previously, Kintor Pharma has completed the Phase I clinical trials of GT20029 both in China and the US, and the top- line data of more than 200 subjects has demonstrated that GT20029 has a good safety profile and is well-tolerated for single and multiple doses of topical application.