On January 1, 2013, Elizabeth L. Hougen was appointed as Senior Vice President, Finance and Chief Financial Officer of Isis Pharmaceuticals, Inc. Ms. B. Lynne Parshall will continue to serve as Chief Operating Officer, Corporate Secretary and as a member of Board of Directors. Ms. Hougen was promoted to Senior Vice President, Finance and Chief Financial Officer on January 1, 2013. From January 1, 2007 to January 2013, Ms. Hougen served as its Vice President, Finance and Chief Accounting Officer and from May 2000 to January 1, 2007, she served as its Vice President, Finance.

Prior to joining Isis in 2000, Ms. Hougen held various positions of increasing responsibility, most recently as Executive Director, Finance and Chief Financial Officer, for Molecular Biosystems, Inc.