Item 7.01 Regulation FD Disclosure.

On January 9, 2023, Denali Therapeutics Inc. (the "Company") issued a press release announcing an update on its programs and expected milestones for 2023 and the Company's participation in the 41st Annual J.P. Morgan Healthcare Conference.

A copy of the press release is attached hereto as Exhibit 99.1 and incorporated herein by reference.

The information furnished in this Item 7.01 and Item 9.01 (including Exhibit 99.1) shall not be deemed to be "filed" for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the "Exchange Act"), or otherwise subject to the liabilities of that section, nor shall it be deemed incorporated by reference into any filing under the Securities Act of 1933, as amended, or the Exchange Act, except as shall be expressly set forth by specific reference in such a filing.

Item 9.01 Financial Statements and Exhibits.



(d) Exhibits

Exhibit No.       Description
99.1                Press release dated January     9, 2023.
104               Cover Page Interactive Data File (formatted as Inline XBRL)

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