AstraZeneca will recover the global rights to brazikumab (formerly MEDI2070), a monoclonal antibody targeting IL23, from Allergan. Brazikumab is currently in a Phase IIb/III programme in Crohn's disease (CD)1 and a Phase IIb trial in ulcerative colitis (UC). AstraZeneca and Allergan will terminate their existing license agreement and all rights to brazikumab will revert to AstraZeneca. The transaction is expected to complete in the first quarter of 2020, subject to regulatory approvals associated with AbbVie's proposed acquisition of Allergan and its timely completion. AstraZeneca's mid to late-stage pipeline of biologic medicines in respiratory and immunology includes Fasenra (benralizumab) which is being evaluated in eight eosinophil-driven diseases beyond severe asthma, tezepelumab in Phase III development for severe, uncontrolled asthma, anifrolumab for the treatment of systemic lupus erythematosus which is being prepared for regulatory submission in the second half of 2020, and MEDI3506 (IL33 monoclonal antibody), a potential new medicine for the treatment of dermatological and other diseases entering Phase II trials.