AstraZeneca : Transaction by Person Discharging Managerial Responsibilities - Form 6-K

Transaction by Person Discharging Managerial Responsibilities

AstraZeneca PLC (the Company) announces that, on 5 May 2023, it was notified of a transaction in the Company's American Depositary Shares (ADSs) by Aradhana Sarin, Chief Financial Officer and Director of the Company, as set out below. Two ADSs are equivalent to one of the Company's ordinary shares of $0.25 each.

PDMR	Position	Nature of the transaction	Quantity	Price
Aradhana Sarin	Chief Financial Officer	Sale of ADSs	19,470	US$74.81

Further details are set out in the attached notification, made in accordance with the requirements of the EU Market Abuse Regulation (as it forms part of UK law pursuant to the European Union (Withdrawal) Act 2018.

1	Details of the person discharging managerial responsibilities / person closely associated
a)	Name	Aradhana Sarin
2	Reason for the notification
a)	Position/status	Chief Financial Officer
b)	Initial notification /Amendment	Initial notification
3	Details of the issuer, emission allowance market participant, auction platform, auctioneer or auction monitor
a)	Name	AstraZeneca PLC
b)	LEI	PY6ZZQWO2IZFZC3IOL08
4	Details of the transaction(s): section to be repeated for (i) each type of instrument; (ii) each type of transaction; (iii) each date; and (iv) each place where transactions have been conducted
a)	Description of the financial instrument, type of instrument Identification code	AstraZeneca PLC American Depositary Shares CUSIP: 046353108
b)	Nature of the transaction	Sale of AstraZeneca PLC American Depositary Shares
c)	Price(s) and volume(s)	Price(s)	Volume(s)
US$74.81	19,470
d)	Aggregated information - Aggregated volume - Price	Not applicable - single transaction
e)	Date of the transaction	5 May 2023
f)	Place of the transaction	XNAS

AstraZeneca

AstraZeneca (LSE/STO/Nasdaq: AZN) is a global, science-led biopharmaceutical company that focuses on the discovery, development, and commercialisation of prescription medicines in Oncology, Rare Diseases, and BioPharmaceuticals, including Cardiovascular, Renal & Metabolism, and Respiratory & Immunology. Based in Cambridge, UK, AstraZeneca operates in over 100 countries and its innovative medicines are used by millions of patients worldwide. Please visit astrazeneca.com and follow the Company on Twitter @AstraZeneca.

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Adrian Kemp

Company Secretary

AstraZeneca PLC