Vigil Neuroscience, Inc. announced the presentation of multiple oral and poster presentations on the Company's lead clinical candidate iluzanebart at the 2024 American Academy of Neurology (AAN) Annual Meeting. The disease generally presents in adults in their forties, is diagnosed through genetic testing and established clinical/radiologic criteria and is characterized by cognitive dysfunction, neuropsychiatric symptoms, and motor impairment. These symptoms typically exhibit rapid progression with a life expectations of approximately six to seven years on average after diagnosis, causing significant patient and caregivers burden.

There are currently no approved therapies for the treatment of ALSP, underscoring the high unmet need in this rare indication. Interim analysis of the Phase 2 IGNITE proof-of-concept, multicenter, open-label study evaluating safety, tolerability, and clinical effects of iluzanebart demonstrated: A favorable safety and tolerability profile; Predictable pharmacokinetic (PK) profile that is supportive of once-monthly dosing; CNS target engagement and downstream pharmacological activity, including increased cerebrospinal fluid (CSF) levels of soluble colony-stimulating factor-1 receptor (sCSF1R), which is emerging as a key biomarker of ALSP disease pathophysiology; Positive trends consistent with slowing of disease progression on key magnetic resonance imaging (MRI) measures in individual patients; Encouraging trend emerging on changes in NfL reduction in individual patients.