“Throughout 2022, we focused on clinical execution to position ourselves for key clinical data readouts for SL-172154 in 2023. These milestones are now rapidly approaching for both solid tumor and hematologic indications. Importantly, in 2022 we completed the monotherapy dose-escalation study and selected a dose of SL-172154 to advance into combination studies with liposomal doxorubicin for patients with platinum-resistant ovarian cancer. In addition, we have established a collaboration with ImmunoGen to combine SL-172154 with mirvetuximab soravtansine, also in the platinum-resistant ovarian cancer patient population. As for our heme program, we are enrolling well and have advanced into the azacitidine combination cohorts for patients with AML or HR-MDS,” said
Key Accomplishments in 2022
ARC Platform
SL-172154 (SIRPα-Fc-CD40L)
- Completed enrollment in Phase 1 dose-escalation clinical trial of SL-172154 as monotherapy in platinum-resistant ovarian cancer
- Dosed first patients in ongoing Phase 1B clinical trial of SL-172154 in combination with liposomal doxorubicin in platinum-resistant ovarian cancer
- Initiated Phase 1B clinical trial of SL-172154 in combination with mirvetuximab soravtansine in platinum-resistant ovarian cancer
- Dosed first patients in first combination cohort with azacitidine in ongoing Phase 1A/B clinical trial of in SL-172154 in acute myeloid leukemia (AML) and higher-risk myelodysplastic syndromes (HR-MDS)
- Provided clinical data for intratumorally administered SL-172154 in Phase 1 clinical trial in squamous cell carcinoma of the head and neck or skin
SL-279252 (PD1-Fc-OX40L)
- Advanced enrollment into final dose-escalation cohorts at 12 and 24 mg/kg in ongoing Phase 1 clinical trial of SL-279252 in advanced solid tumors and lymphomas
SL-9258 (TIGIT-Fc-LIGHT)
- Presented data on the preclinical development of SL-9258 at the Protein and Antibody Engineering Summit (PEGS) conference and published the associated preclinical manuscript in the
Journal of Immunology - Presented preclinical data on SL-9258 at the
American Association for Cancer Research (AACR) Annual Meeting
GADLEN Platform
GADLEN Preclinical Product Candidates
- Announced two potential lead candidates from the GADLEN platform in 2023, one targeting the CD20 antigen intended for development in autoimmune disease and a second targeting the B7H3 antigen for development in oncology
- Data from two potential lead candidates were presented at both the
Gamma Delta T Therapies Summit Meeting and Society for Immunotherapy of Cancer (SITC) Annual Meeting
Clinical Milestones Expected in 2023
ARC Platform
SL-172154 (SIRPα-Fc-CD40L)
- Complete data from Phase 1 dose-escalation clinical trial of SL-172154 as monotherapy in platinum-resistant ovarian cancer expected midyear 2023
- Initial data from Phase 1B clinical trial of SL-172154 in combination with liposomal doxorubicin in platinum-resistant ovarian cancer expected midyear 2023
- Initial dose-escalation data, as monotherapy and in combination with azacitidine, for Phase 1A/B clinical trial of SL-172154 in AML and HR-MDS expected in 1H’2023
- Complete dose-escalation data, as monotherapy and in combination with azacitidine, for Phase 1A/B clinical trial of SL-172154 in AML and HR-MDS and initial dose-expansion cohort data expected in 2H’2023
- Initial data from Phase 1B clinical trial of SL-172154 in combination with mirvetuximab soravtansine in platinum-resistant ovarian cancer expected 2H’2023
SL-279252 (PD1-Fc-OX40L)
- Go/no-go decision from the Phase 1 dose-escalation clinical trial of SL-279252 in advanced solid tumors or lymphoma in 1Q’2023
GADLEN Platform
GADLEN Preclinical Product Candidates
- Additional clinical development detail and further program guidance regarding the advancement of potential product candidates from the GADLEN platform in 2023
Cash Position and Financial Guidance
Upcoming Presentations
Conference: 41st Annual J.P. Morgan Healthcare Conference
Format: Corporate Presentation
Presenter: Taylor Schreiber, M.D., Ph.D., Shattuck’s Chief Executive Officer
Date: January 12, 2023
Time: 2:15 p.m. ET
A live audio recording of the presentation will be available on the Investors section of the Company’s website. A replay of the webcast will be archived for up to 30 days following the presentation date.
About
Forward-Looking Statements
Certain statements in this press release may constitute “forward-looking statements” within the meaning of the federal securities laws, including, but not limited to, our expectations regarding plans for our preclinical studies, clinical trials and research and development programs, the anticipated timing of the results from our clinical trials, anticipated timing for preclinical development updates, potential clinical benefit of our product candidates, and expectations regarding the time period over which our capital resources will be sufficient to fund our anticipated operations. Words such as “may,” “might,” “will,” “objective,” “intend,” “should,” “could,” “can,” “would,” “expect,” “believe,” “design,” “estimate,” “predict,” “potential,” “develop,” “plan” or the negative of these terms, and similar expressions, or statements regarding intent, belief, or current expectations, are forward-looking statements. While we believe these forward-looking statements are reasonable, undue reliance should not be placed on any such forward-looking statements, which are based on information available to us on the date of this release. These forward-looking statements are based upon current estimates and assumptions and are subject to various risks and uncertainties (including, without limitation, those set forth in our filings with the
The Company intends to use the investor relations portion of its website as a means of disclosing material non-public information and for complying with disclosure obligations under Regulation FD.
Investor & Media Contact:
Vice President of Investor Relations
InvestorRelations@shattucklabs.com
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