Rhythm Pharmaceuticals, Inc. announced that the company delivered three presentations - one oral and two posters - at The Pediatric Endocrine Society's (PES) Annual Meeting held May 2-5, 2024 in Chicago, IL. In the oral presentation, Rhythm showcased data that was previously announced on December 6, 2023, from its 52-week, Phase 3 pediatrics trial in patients between the ages of 2 and younger than 6 years (N=12) with Bardet-Biedl syndrome (BBS) or obesity due to proopiomelanocortin (POMC) or leptin receptor (LEPR) deficiency. Treatment with setmelanotide achieved the primary endpoint with a 3.04 mean reduction in BMI-Z score (a measure of body mass index deviations from what is considered normal) and 18.4% mean reduction in body mass index (BMI).

Rhythm remains on track to complete submission of a supplementary New Drug Application (sNDA) to the U.S. Food and Drug Administration (FDA) seeking a label expansion to treat pediatric patients between the ages of 2 and younger than 6 years in approved indications in the first half of 2024.