Certain Common Stock of Ra Pharmaceuticals, Inc. are subject to a Lock-Up Agreement Ending on 11-MAR-2019. These Common Stock will be under lockup for 90 days starting from 11-DEC-2018 to 11-MAR-2019. Details: The directors, officers, and other stockholders have agreed that they will not offer, sell, contract to sell, pledge or otherwise dispose of, directly or indirectly, any shares of common stock or securities, convertible into or exchangeable or exercisable for any shares of common stock, for aperiod of 90 days after the date of prospectus without the prior written consent of Jefferies LLC, BMO Capital Markets Corp. and Stifel, Nicolaus & Company, Incorporated.