Prescient Therapeutics announced its internal development programs for OmniCAR, a next-generation CAR-T therapy platform. OmniCAR is a universal immune receptor technology platform that offers a number of potential benefits over existing CAR-T therapies, including control, safety, flexibility and efficacy. With a platform technology with such a broad range of potential applications, it was important for Prescient to strategically select indications and applications for internal development that struck a balance between market opportunity, technical complexity and product differentiation. The strategic review was led by Prescient and its Scientific Advisory Board. The review took into account all the known CAR-T programs in development worldwide and had input from leaders from multiple disciplines, including the inventors; clinicians; researchers; venture capitalists and healthcare investors; leading non-profit cancer organizations and antibody experts. Prescient announced three internal programs representing significant market opportunities, where current-generation CAR-T have faced challenges, but where the unique capabilities of OmniCAR may present distinct advantages. The development programs are: OmniCAR CD33 and CLL-1 for Acute Myeloid Leukemia (AML); OmniCAR Her2 for Her2+ solid tumours including breast, ovarian and gastric cancers; and OmniCAR Her2 and EGFRviii for glioblastoma multiforme (GBM). The application of OmniCAR technology in these cancers is expected to have benefits over conventional CAR T therapy, including: titration for improved safety; the ability to switch antigen targeting; co-arming CAR-T against multiple antigens simultaneously; persistent dosing and tumour microenvironment enhancements to improve efficacy. The vigorous development program will move OmniCAR towards clinical programs while demonstrating the unique features of the technology in treating patients, which will add tremendous value to the OmniCAR platform.