Opthea Limited announced that the Phase 2b study results of OPT-302, the Company's anti-VEGF-C/-D “trap” agent administered in combination with Lucentis® (ranibizumab) for the treatment of wet age-related macular degeneration (AMD), have been published online in Ophthalmology, the journal of the American Academy of Ophthalmology The prospective, randomized, controlled Phase 2b trial of 366 treatment-naïve patients with wet AMD, conducted at 109 clinical sites across the United States, Europe and Israel, demonstrated that monthly intravitreal administration of 2.0 mg OPT-302 with ranibizumab standard of care, met the pre-specified primary efficacy endpoint of a statistically superior gain in visual acuity at 24 weeks, compared to ranibizumab alone. In addition, secondary outcomes were positive for the OPT-302 combination therapy including more participants with gains in vision of10 or more letters, improved anatomy of reduction in swelling and vascular leakage, with a favorable safety profile. The U.S. Food and Drug Administration (FDA) granted OPT-302 Fast Track Designation for the treatment of wet AMD, which facilitates the development and expedites the review of investigational therapies to treat serious conditions and fill an unmet medical need.