Nurix Therapeutics, Inc. announced that the company will present clinical trial design details for three of its wholly-owned investigative therapies, NX-2127, DeTIL-0255 and NX-1607, each currently in Phase 1 development, at the Annual Meeting of the American Society of Clinical Oncology (ASCO). The meeting is being held from June 3-7, 2022 in Chicago, IL and virtually. Poster and presentation details are included below: Title:A First-in-Human Phase 1 Trial of NX-2127, a First-in-Class Oral BTK Degrader With Immunomodulatory Activity, in Patients With Relapsed and Refractory B-Cell Malignancies; Authors: Anthony Mato, Alexey Danilov, Manish R. Patel, Michael Tees, Ian Flinn, Weiyun Ai, Krish Patel, Michael Wang, Susan O'Brien, Srinand Nandakumar, May Tan, Erin Meredith, Melissa A. Gessner, Su Young Kim, Adrian; Wiestner, William G. Wierda Session: Hematologic Malignancies—Lymphoma and Chronic Lymphocytic Leukemia Abstract: TPS7581; Poster: 232a Time: June 4, 8:00 a.m. - 11:00 a.m. CDT Title:A Phase 1 Adoptive Cell Therapy Using Drug-Enhanced, Tumor-Infiltrating Lymphocytes, DeTIL-0255, in Adults With Advanced Malignancies Authors: Eugenia Girda, Emese Zsiros, John Nakayama, Sarah Whelan, Srinand Nandakumar, Seema Rogers, Beverly Benson, Frank G. Basile, Michael T. Lotze, Robert Brown, and Robert M. Wenham Session: Gynecologic Cancer; Abstract: TPS5602; Poster: 477b; Time: June 4, 1:15 p.m. - 4:15 p.m. CDT.

Title:A First-in-Human Phase 1 Trial of NX-1607, a First-in-Class Oral CBL-B Inhibitor, in Patients with Advanced Solid Tumor Malignancies; Authors: Adam Sharp, Anja Williams, Sarah Blagden, Ruth Plummer, Daniel Hochhauser, Matthew G. Krebs, Simon Pacey, Jeff Evans, Sarah Whelan, Srinand Nandakumar, Seema Rogers, Katherine L. Jameson, Frank G. Basile, Johann de Bono, and Hendrik-Tobias Arkenau; Session: Developmental Therapeutics—Immunotherapy; Abstract: TPS2691; Poster: 333b; Time: June 5, 8:00 a.m. - 11:00 a.m. CDT. Posters will be available for registered attendees for on-demand viewing on the ASCO website. They can also be viewed on the Events and Presentations page of the Investors section of Nurix's website at the date and time of the poster presentation.

NX-2127 is a novel bifunctional molecule that degrades Bruton's tyrosine kinase (BTK) and cereblon neosubstrates Ikaros (IKZF1) and Aiolos (IKZF3). NX-2127 is currently being evaluated in a Phase 1a/1b clinical trial in patients with relapsed or refractory B cell malignancies. Initial data from the Phase 1a dose-escalation portion of the study demonstrated clinically meaningful degradation of BTK in all patients, including in a chronic lymphocytic leukemia patient with significant mutations in the BTK gene associated with resistance to standard of care BTK inhibitors.

Nurix expects to present additional data from this study in the second half of 2022. DeTIL-0255 is an autologous cell therapy consisting of T cells derived from a patient's tumor expanded in culture with recombinant interleukin-2 and the small molecule Casitas B-lineage lymphoma proto-oncogene B (CBL-B) inhibitor NX-0255. DeTIL-0255 is designed to be a single administration autologous TIL therapy infused following non-myeloablative chemotherapy.

Given the improved phenotypes of T cells produced with CBL-B inhibition, DeTIL-0255 could allow a broader application of TIL therapy, potentially providing long term benefit to patients with multiple types of cancer. Nurix is conducting a Phase 1 trial of DeTIL-0255 in patients with advanced gynecologic tumors at multiple sites in the United States. NX-1607 is an orally bioavailable inhibitor of CBL-B for immuno-oncology indications including a range of solid tumor types.

NX-1607 acts on T cells, NK cells, and dendritic cells to enhance anti-tumor immunity, and has demonstrated single-agent anti-tumor activity in multiple tumor models. Nurix is evaluating NX-1607 in an ongoing, Phase 1 dose escalation and expansion trial in adults with a variety of oncology indications at multiple clinical sites in the United Kingdom.