Moolec Science SA announced that the Animal and Plant Health Inspection Service of the U.S. Department of Agriculture has concluded that Moolec's GLA safflower plants pose no greater plant pest risk than non-genetically engineered safflower plants according to regulation found at 7 CFR part 340. According to USDA-APHIS regulation found at 7 CFR part 340, developers may submit a request for a RSR when they believe a genetically engineered ("GE") plant is not subject to the regulation. APHIS reviews the GE plant and considers whether it might pose an increased plant pest risk compared to its non-GE comparator.

If APHIS does not identify a greater pest risk relative to the comparator, the GE plant is not subject to this regulation. Regulation 7 CFR part 340 governs the importation, interstate movement, and the environmental release of certain organisms that have been modified or produced by genetic engineering.