(“Avacta” or the “Group” or the “Company”)
- AVA3996: FAP-α-activated proteasome inhibitor from pre|CISIONTM platform concentrates proteasome inhibitor payload in the tumour, increasing the therapeutic index of this class of drugs
- AVA032: anti-PD-L1 Affimer® fused to IL-15 demonstrates encouraging in vitro and in vivo efficacy
Details of the poster presentations are as follows:
Abstract title: AVA3996, a novel pre|CISION™ medicine, targets a warhead to the tumor microenvironment via Fibroblast Activation Protein (“FAP”) mediated cleavage to elicit tumor cell kill
Poster number: C169
Session: Poster Session C
Session date and time:
Session location: Level 2, Exhibit Hall D
Abstract title: A novel, tumor-targeted immunocytokine comprising an anti-PD-L1 Affimer® fused to IL-15 exhibits potent anti-tumor activity
Poster number: A077
Session: Poster Session A
Session date and time:
Session location: Level 2, Exhibit Hall D
Dr
“We look forward to presenting the promising new data from Avacta’s Therapeutics platform assets at this conference. As disclosed in the Company’s announcement on
“AVA3996, a FAP-α-activated proteasome inhibitor based on our pre|CISIONTM technology, demonstrates targeted killing of cancer cells in vitro and, by concentrating the active warhead in the tumour, reduces systemic toxicity associated with this class of drug.
“AVA032, our anti-PD-L1 Affimer® fused to the pro-inflammatory cytokine interleukin 15 (IL-15) displays encouraging efficacy when tested in multiple models of immunomodulation, stimulating a potent immune response and reversing the immunosuppressive tumour microenvironment.”
Further information regarding the conference can be found on the ACCR’s website here: https://www.aacr.org/meeting/aacr-nci-eortc-international-conference-on-molecular-targets-and-cancer-therapeutics-2/
The posters will be available to view following the conference here: https://avacta.com/about/scientific-resources/
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For further information from
Tel: +44 (0) 1904 21 7070 www.avacta.com | |
Tel: +44 (0) 207 710 7600 www.stifel.com | |
Peel | Tel: +44 (0) 207 418 8900 www.peelhunt.com |
ICR Consilium (Media and IR) | avacta@consilium-comms.com |
About
The pre|CISION™ platform modifies chemotherapy to be activated only in the tumour tissue, reducing systemic exposure and toxicity. This is achieved by harnessing an enzyme called FAP which is highly upregulated in most solid tumours compared with healthy tissues, turning chemotherapy into a “precision medicine”. The lead pre|CISION™ programme, AVA6000 a tumour activated form of doxorubicin, is in Phase 1 studies and has shown dramatic improvement in safety compared with standard doxorubicin, and early signs of clinical activity.
Affimer® is a novel biologic platform which has significant technical and commercial advantages compared with antibodies and is used both to develop advanced immunotherapies and to improve the performance of immunodiagnostics.
With a balanced business and capital allocation model: a high-value oncology pipeline supported by a revenue generating, fast-growing diagnostics business,
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About AVA3996
AVA3996 is a FAP-α-activated proteasome inhibitor, based on the Company’s pre|CISIONTM technology platform. AVA3996 has the potential to become a targeted cancer treatment for various indications, overcoming cytotoxicity issues displayed when the free, non-targeted form of proteasome inhibitor is systemically administered to patients.
About AVA032
AVA032 is an anti-PD-L1 Affimer® fused to the cytokine interleukin 15 (“IL-15”). It carries improved properties compared to monoclonal antibodies, currently used as cancer therapeutics, and works to reverse the immunosuppressive tumour micro-environment, inducing a lasting immune response aimed at stimulating a patient’s immune system to destroy cancer cells.
Source:
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