Arcutis Biotherapeutics, Inc. announced that the Journal of Clinical and Aesthetic Dermatology (JCAD) published the outcomes of a comprehensive evaluation by an expert dermatologist panel assessing the formulation ingredients of ZORYVE (roflumilast) topical foam, 0.3%. ZORYVE foam is a once-daily steroid-free treatment for seborrheic dermatitis. The published article supports the use of ZORYVE foam in all hair and skin types.

Consultation with an expert dermatologist panel composed of leading medical and cosmetic dermatologists with expertise in formulation from medical centers, dermatology clinics, and academic institutions across the United States confirms that the formulation of ZORYVE foam excludes harmful ingredients including thickening agents, alcohol, fragrances, essential oils, and oxidizing agents. In addition, Arcutis is the first company to formulate a pharmaceutical product with Crodafos CES, an emulsifier used in the skin and beauty industry due to its versatility and effectiveness across skin and hair types. Upon thorough review of the formulation data, eight out of nine experts expressed feeling ?extremely confident?

about using roflumilast foam with patients of diverse skin and hair types, including individuals with previous hair treatments. Seborrheic dermatitis affects up to 10 million people in the United States and is a common, chronic, and recurrent inflammatory skin disease that causes red patches covered with large, greasy, flaking yellow scales and persistent itch. Seborrheic dermatitis occurs most often in areas of the body with oil-producing (sebaceous) glands, including the scalp, face (especially on the nose, eyebrows, ears, and eyelids), upper chest, and back.

ZORYVE foam is the first drug with a new mechanism of action approved for seborrheic dermatitis in over two decades. ZORYVE (roflumilast) topical foam, 0.3%, is indicated for treatment of seborrheic dermatitis in adult and pediatric patients 9 years of age and older. ZORYVE foam is a topical foam formulation of roflumilast, a highly potent and selective phosphodiesterase-4 (PDE4) inhibitor.

PDE4 is an intracellular enzyme that increases the production of pro-inflammatory mediators and decreases production of anti-inflammatory mediators and is an established target in dermatology. ZORYVE foam, 0.3%, is indicated for treatment of seborrheic dermatitis in adult and pediatric patients 9 years of age and older.