Item 8.01 Other Events.

Agios Pharmaceuticals, Inc. (the "Company") expects to hold the 2022 annual meeting of stockholders of the Company (the "2022 Annual Meeting") on Tuesday, June 21, 2022 to be held virtually via the internet. The virtual attendance instructions of the 2022 Annual Meeting will be set forth in the Company's proxy statement for the 2022 Annual Meeting, to be electronically filed prior to the 2022 Annual Meeting with the U.S. Securities and Exchange Commission.

The expected date of the 2022 Annual Meeting is more than 30 days following the anniversary of the Company's 2021 annual meeting of stockholders (the "2021 Annual Meeting"). As a result, pursuant to Rule 14a-8 under the Securities Exchange Act of 1934, as amended, the deadline for receipt of stockholder proposals for inclusion in the Company's proxy statement for the 2022 Annual Meeting pursuant to Rule 14a-8 has been set at January 28, 2022. In order for a proposal under Rule 14a-8 to be considered timely, it must be received by the Company on or prior to January 28, 2022 at the Company's principal executive offices at 88 Sidney Street, Cambridge, Massachusetts 02139 and be directed to the attention of the Corporate Secretary. All stockholder proposals must be in compliance with applicable laws and regulations in order to be considered for inclusion in the proxy statement for the 2022 Annual Meeting.

Under the Company's bylaws, stockholders may also present a proposal or director nomination at the 2022 Annual Meeting, which will not be included in the Company's proxy statement for the 2022 Annual Meeting, if advance written notice is timely given to the Corporate Secretary of the Company, at the Company's principal executive offices, in accordance with the Company's bylaws. As the Company disclosed in its proxy statement for the 2021 Annual Meeting, to be timely, notice by a stockholder of any such proposal or nomination must be provided no later than February 19, 2022, but not before January 20, 2022. The Company's bylaws specify requirements relating to the content of the notice that stockholders must provide.

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