WuXi Biologics announced that it has launched WuXiaADCC PLUSTM, a superior-performing and high-yielding mammalian cell line platform for the development and manufacturing of afucosylated antibodies to elicit an enhanced ADCC response. ADCC is recognized as a crucial mechanism underlying targeted antibody-based immunotherapy approaches. The development of novel cancer therapies entails designing and engineering antibodies with increased ability to heighten the ADCC response, which is known to improve therapeutic efficacy and patient outcomes.

Removal of fucose on the N-glycosylation site is an efficient and cost-effective way to enhance ADCC activity and increase the potency of antibody-based immunotherapies. To meet growing global demand for the production of afucosylated antibodies, the WuXiaADCC PLUSTM cell line was derived from the WuXi Biologics' highly-vetted WuXiaTM cell line. The WuXiaADCC PLUSTM cell line is compatible with the WuXiaTM platform process, which enables the stable production of the afucosylated antibodies at various scales for clinical and commercial manufacturing.