TransCode Therapeutics, Inc. will present data from a Phase 0 clinical trial with its lead candidate, TTX-MC138, at this year's San Antonio Breast Cancer Symposium scheduled to take place December 5-9 in San Antonio, TX. The abstract, "Development of TTX-MC138, a First-In-Class miRNA-10b-Targeted Therapeutic Against Metastatic Cancers of Diverse Primary Disease Origins" will be presented as a poster. The poster will describe the clinical development of TTX-MC138., a therapeutic miR-10b inhibitor, delivered to metastatic tumor cells that has expedited complete responses and life-long disease remissions in preclinical models of adenocarcinoma.

Second, the Phase 0 trial has the potential to reveal the pharmacokinetic behavior of TTX-MC138 which could inform dosing during therapy. Third, if TTX-MC138 reaches late-stage clinical trials, the radiolabeled therapeutic candidate could be used to select patients for treatment in the trial based on which patients' metastases accumulate the drug candidate. TransCode believes that these results also have the potential to support further clinical trials using TTX-MC138 to treat metastatic cancer and, by addressing the issue of drug delivery, enable clinical development of a wide array of TTX-based therapeutic candidates.