ELK CITY -
This neurodegenerative disease is the leading cause of dementia in patients under 60 years old and to date no therapies have been shown to reduce its progression1.
Frontotemporal dementia is caused by a buildup of particular proteins that form clumps inside brain cells, causing brain inflammation and activation of certain immune cells which result in damage to the frontal and temporal lobes. These patients eventually die of the disease but before death suffer horrific effects. For example, in the behavioral variant, which is the most common form of the condition, severe personality changes occur, which include apathy, and a progressive decline in socially appropriate behavior, judgment, self-control, and empathy. In the primary progressive aphasia variant of this condition, gradual loss of the ability to speak, read, write, and understand what others are saying occurs, basically isolating the patient.
'We have previously had success in treating patients suffering from chronic traumatic encephalopathy (CTE) using the JadiCell cell therapy product, administered under the Right to Try Law,' said Dr.
Various inflammatory mechanisms have been implicated in disease progression in both chronic traumatic encephalopathy and frontotemporal dementia. One area of particular interest is the ability of JadiCells to inhibit inflammasome activation as well as downstream chemical messengers of this inflammatory pathway, while concurrently stimulating regeneration of damaged neurons.
'Our new data and the recent findings supporting the possibility of JadiCell-based neural regeneration for Frontotemporal Dementia supports the idea that the JadiCell platform can be leveraged in a variety of disease indications,' said
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