On May 17, 2024 (the ?Effective Date?), Scholar Rock Holding Corporation (the ?Company?) and Scholar Rock, Inc., a wholly-owned subsidiary of the Company (?Scholar Rock? and collectively with the Company, the ?Borrower?), entered into the Fourth Amendment (?Loan Amendment No. 4?) to the Loan and Security Agreement, dated October 16, 2020, by and with Oxford Finance LLC and Silicon Valley Bank (each, a ?Lender?

and collectively, the ?Lenders?). Pursuant to the Loan Agreement, the company previously received $50 million in loan proceeds under the Loan Agreement. Pursuant to Loan Amendment No.

4, the company and the Lenders agreed to amend the milestones required to access an additional tranche of $25.0 million that is available to the company under the Loan Agreement. The fourth tranche is available at discretion through December 2024, upon achievement of certain clinical and business milestones. Loan Amendment No.

4 also extended the interest-only payment period for an additional six months through May 2025, with principal payments to commence in June 2025, or for an additional six months through November 2025 upon achievement of certain business performance milestones, with principal payments to commence in December 2025.