Item 5.02 Departure of Directors or Certain Officers; Election of Directors;


          Appointment of Certain Officers; Compensatory Arrangements of Certain
          Officers.


(d)

On January 20, 2022, the Board of Directors (the "Board") of Reneo Pharmaceuticals, Inc. (the "Company"), upon recommendation of the Nominating and Corporate Governance Committee of the Board, appointed Paul Hoelscher as (i) a Class I director of the Company, with a term of office expiring at the 2022 annual meeting of stockholders, (ii) a member of the Audit Committee of the Board (the "Audit Committee") and (iii) Chair of the Audit Committee (to succeed Eric Dube, Ph.D. in such role, although Dr. Dube will remain as a member of the Audit Committee). There are no arrangements or understandings between Mr. Hoelscher and any other person pursuant to which he was selected as a director. In addition, there are no transactions in which Mr. Hoelscher has an interest that would require disclosure under Item 404(a) of Regulation S-K.

Pursuant to the Company's Non-Employee Director Compensation Policy (the "Compensation Policy"), Mr. Hoelscher (i) will receive an (a) annual cash retainer of $40,000 for service on the Board and (b) additional annual cash retainer of $15,000 for service as Chair of the Audit Committee, and (ii) was granted on the date of his appointment an option to purchase 35,000 shares of the Company's common stock, which vests in equal monthly installments over a three-year period. The Compensation Policy also provides for further automatic annual option grants to purchase a specified number of shares of the Company's common stock on the date of each annual meeting of stockholders (which will be pro-rated for Mr. Hoelscher's first annual option grant), which vest in full on the earlier of (x) the one-year anniversary of the date of grant or (y) the day prior to the date of the Company's next annual stockholder meeting. Each of the option grants described above will vest in full in the event of a change in control (as defined in the Company's 2021 Equity Incentive Plan). Mr. Hoelscher has also entered into the Company's standard form of Indemnification Agreement.

(b)

On January 18, 2022, Lon Cardon, Ph.D. informed the Company that he will not stand for re-election as a member of the Board when his term as a Class I director expires at the Company's 2022 annual meeting of stockholders. Dr. Cardon recently assumed the role of President and Chief Executive Officer of The Jackson Laboratory, a non-profit biomedical research institution, and due to institutional policy will be unable to serve on the Board beyond his current term. On January 20, 2022, Kenneth Harrison, Ph.D. resigned from the Board to focus on other endeavors. Neither Dr. Cardon's decision not to stand for re-election nor Dr. Harrison's resignation was the result of any dispute or disagreement with the Company on any matter relating to the operations, policies or practices of the Company.

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