ITEM 5.02 DEPARTURE OF DIRECTORS OR CERTAIN OFFICERS; ELECTION OF DIRECTORS; APPOINTMENT OF CERTAIN OFFICERS; COMPENSATORY ARRANGEMENTS OF CERTAIN OFFICERS.

(e) Compensatory Arrangements of Principal Executive Officer, Principal Financial Officer and Named Executive Officers

2021 Corporate Goals and Bonus Information

On January 19, 2021, the Compensation Committee (the "Committee") of Cortexyme, Inc. (the "Company") approved the Company's 2021 corporate objectives for purposes of determining bonuses, if any, for the Company's executive officers with respect to 2021 performance.

The Company's 2021 corporate goals include the achievement of specified milestones relating to: (i) the Company's GAIN trial and clinical execution and engagement; (ii) the Company's other ongoing clinical trials and pipeline opportunities; (iii) ongoing management of preclinical and chemical, manufacturing and control (CMC) development milestones; (iv) the Company's operating plan and corporate governance/compliance; (v) market development and engagement; and (vi) commercialization planning.

The cash bonus for executive officers will be based on the achievement of the 2021 corporate goals. The executive officers' actual bonuses for fiscal year 2021 may exceed 100% of his or her 2021 target bonus percentage in the event performance exceeds the predetermined goals and/or upon the achievement of other specified goals. Payment of bonuses to the Company's executive officers under the 2021 bonus program and the actual amount of such bonus, if any, are at the discretion of the Committee or the Board.

2020 bonus payouts and target performance bonus percentages for fiscal year 2021 for the Company's named executive officers are set forth below. Target performance bonus percentages are expressed as a percentage of the corresponding 2021 annual base salary.





                                                                             2021 Target Bonus
Name                                            2020 Bonus Payout               Percentage
Casey C. Lynch, President and Chief
Executive Officer                              $           262,500                           55 %
Christopher Lowe, Chief Financial
Officer                                        $           156,000                           40 %
Michael Detke, M.D., Ph.D., Chief
Medical Officer                                $           164,000                           40 %
Stephen S. Dominy, M.D., Chief
Scientific Officer                             $           156,000                           40 %

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