Prosperity Bancshares : Click here for presentation material

4th Quarter 2016

: Forbes 2016 BEST BANKS I N A MERICA

Pro peri ty Ba nk h a been ra n ked i n the

Top Ten of Forbes' Ameri ca's Best Banks

f or fi ve yea r i n a row; twi ce bei ng n am ed

Best Bank in America in 2012 and 2014.

PROSPERITY BANCSHARES INC.

2

"Safe Harbor" Statement

under the Private Securities Litigation Reform Act of 1995

Statements contained in this presentation which are not historical facts and which pertain to future operating results of Prosperity Bancshares®, Inc. and its subsidiaries constitute "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995. These forward-looking statements involve significant risks and uncertainties. Actual results may differ materially from the results discussed in these forward-looking statements. Factors that might cause such a difference include, but are not limited to, those discussed in the company's periodic reports and filings with the SEC. Copies of the SEC filings for Prosperity Bancshares® may be downloaded from the Internet at no charge from www.prosperitybankusa.com.

3

4Q16 Highlights

• Net Income of $68.793 million and earnings per share (diluted) of $0.99 for three months ending December 31, 2016
• Assets of $22.331 billion, loans of $9.622 billion, and deposits of $17.307 billion at December 31, 2016
• Common equity tier 1 ratio was 14.48% and leverage ratio was 8.68% at December 31, 2016
• Sound asset quality with annualized net charge offs/average loans of 0.09% for the fourth quarter 2016
• Non-performing assets to average earning assets remain low at 0.25% or $40.302 million for the fourth quarter 2016
• Declared cash dividend of $0.34 per share for the fourth quarter 2016

4