On June 28, 2024, Lexicon and one of its subsidiaries entered into a sixth amendment (the Sixth Amendment) to its loan and security agreement (the Loan Agreement) with Oxford Finance LLC and the lenders listed therein extending the interest-only period under the loans thereunder with an amortization date of May 1, 2027, extending the maturity date of the loans thereunder to March 1, 2029, modifying the existing financial covenants relating to net sales of INPEFA ® (sotagliflozin) and minimum cash reserves and increasing the final payment due upon prepayment or maturity of the loans thereunder.