On August 9, 2019, Ms. Karen S. Wright notified Jaguar Health, Inc. of her decision to resign as Chief Financial Officer and Treasurer of the Company, effective immediately. On August 13, 2019, the Company's Board of Directors appointed Carol R. Lizak, age 55, as the Company's Chief Accounting Officer, effective immediately. Ms. Lizak, who currently serves as Vice President of Finance and Corporate Controller of the Company, will assume the duties of the Company's principal financial officer and principal accounting officer.

Ms. Lizak joined the Company in May 2019 as Vice President of Finance and Corporate Controller. Prior to joining the Company, Ms. Lizak served as Senior Director and Corporate Controller of Zosano Pharma Corporation from November 2017 to January 2019, as Controller of Quantum Secure, Inc. from July 2016 to August 2017, and as Executive Director, Corporate Controller of Alexza Pharmaceuticals, Inc. from September 2014 to July 2016.