The following discussion and analysis should be read in conjunction with the
Consolidated Financial Statements and notes thereto included in this Report. In
addition to the historical information contained herein, the discussions in this
Report may contain forward-looking statements that may be affected by risks and
uncertainties, including those discussed in Item 1A, Risk Factors. Our actual
results could differ materially from those discussed in the forward-looking
statements, as discussed in the section entitled "Cautionary Note Regarding
Forward-Looking Statements" in this Report.

References to fiscal years, years or portions of years in this Item refer to our fiscal year ended September 30, unless otherwise indicated.

Recent Developments and Executive Summary


During recent periods, we have undertaken significant internal and external
growth initiatives. Our growth initiatives include (1) acquisitions, (2)
expansion of existing and acquired businesses, and (3) startup of new services.
Prior to fiscal year 2022, our growth initiatives focused on discovery and
safety assement (DSA) services, and, as a result of our strategic acquisition of
Envigo RMS Holding Corp. ("Envigo") in November 2021, which added a
complementary research model platform, our full spectrum solutions now span two
segments: Discovery and Safety Assessment ("DSA") and Research Models and
Services ("RMS"). In addition to growth initiatives in fiscal year 2022, we have
also announced site optimization plans in the U.S. and our intent to consult
with employee respresentatives for a proposed consolidation of certain European
and U.K. sites, in order to enhance margins.

Acquisitions

DSA



We acquired the business of Seventh Wave Laboratories, LLC, in July 2018 (the
"Seventh Wave Acquisition"), acquired the toxicology business of Smithers Avanza
on May 1, 2019 (the "Smithers Avanza Acquisition"), acquired the preclinical
testing business of Pre-Clinical Research Services, Inc. as well as related real
property, on December 1, 2019 (the "PCRS Acquisition"), acquired substantially
all of the assets of HistoTox Labs, Inc. ("HistoTox Labs") on April 30, 2021
(the "HistoTox Acquisition"), acquired Bolder BioPATH, Inc. ("Bolder BioPATH")
on May 3, 2021 (the "Bolder Merger"), acquired certain assets related to genetic
toxicology services from BioReliance in July, 2021 (the "BioReliance
Acquisition"), and completed the purchase of all of the outstanding equity
interests in Gateway Pharmacology Laboratories, LLC ("Gateway Laboratories") on
August 2, 2021 (the "Gateway Acquisition").

During the twelve months ended September 30, 2022, we continued our momentum
building Inotiv into a comprehensive provider of preclinical drug discovery and
safety assessment services through our strategic acquisitions of Plato
BioPharma, Inc. ("Plato"), Integrated Laboratory Systems, LLC ("ILS"), Histion,
LLC ("Histion"), Protypia, Inc. ("Protypia") and our collaboration with Synexa
Life Sciences. Plato brings us important new in vivo pharmacology capabilities,
ILS complements our BioReliance® genetic toxicology assets and accelerates the
buildout of our genetic toxicology offerings as well as expanding our general
rodent toxicology capacity. In addition, ILS allows us to provide a
computational toxicology service to provide predictive toxicology assessments.
Histion accelerates our development and growth into the highly-specialized
plastics and medical device histopathology business and Protypia enhances our
ability to support clients in the development of safe and effective medicines,
particularly in the areas of immuno-oncology and cell and gene therapy by
bringing bioanalytical capability to solid tissue specimens. The partnership
with Synexa Life Sciences enhances our large molecule bioanalysis and biomarker
platform. Over the last few years, we've significantly broadened and scaled our
DSA business, enabling one-stop-shop preclinical programs and quicker speed to
market, positioning Inotiv as a primary contract research provider for our

growing client base.

RMS

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During the twelve months ended September 30, 2022 and following the Envigo
acquisition, we took steps to leverage our existing RMS capacity with the
acquisition of Robinson Services Inc.'s ("RSI") rabbit breeding business and we
acquired Orient BioResource Center, Inc. ("OBRC"), which provided access to
additional non-human primate facilities. In an environment during which global
research model demand outstrips supply, these moves mitigate potential supply
bottlenecks as we pursue a multitude of cross-selling and growth opportunities
across our integrated services.

Expansions of Existing and Acquired Businesses


During the twelve months ended September 30, 2022, we initiated a facility
expansion to our facility in Boulder, Colorado ("Boulder facility"), which was
completed in December 2022, we invested in infrastructure, equipment and
facility upgrades to increase revenue capacity at our facility in Morrisville,
North Carolina ("Morrisville facility"), which was complete in December 2022;
and we invested in a buildout of a newly leased 48,000 square foot facility in
Rockville, Maryland ("Rockville facility") to support biotherapeutics and
genetic toxicology growth, which is expected to be complete by March 2023. In
addition, we made significant investments in upgrading facilities and equipment
across the facilities that serve the RMS segment in order to implement planned
and proposed site optimizations and enhance animal welfare. Further, we have
filled critical leadership and scientific positions.

New Service Offerings



We announced new service offerings which we are building internally and startup
operations, including mechanistic pharmacology and toxicology, safety
pharmacology, juvenile toxicology, SEND (Standard for the Exchange of
Nonclinical Data) data reporting; clinical pathology; biotherapeutics;
histopathology for devices; genetic toxicology; and cardiovascular safety
pharmacology. In fiscal years 2022 and 2021, we incurred start up costs of $5.7
million and $1.5 million, respectively.

Restructurings and Site Optimization Plans



In addition to two sites that Envigo announced closing prior to our acquisition
of Envigo, we announced in June 2022 that we were closing a purpose-bred canine
facility in Cumberland, Virgina and a rodent breeding facility in Dublin,
Virginia as part of restructuring activities. The rodent breeding operations
were consolidated into an existing, recently renovated site. The Cumberland
facility closure was completed in September 2022 and the Dublin facility closure
was completed in November 2022. On November 29, 2022, the Company announced
additional site consolidation plans in the U.S., intent to consult with employee
representatives for a proposed consolidation of certain European and U.K. sites,
and provided an update on site optimization plans in process. The site
optimization plans are intended to allow us to reduce overhead and create
efficiencies through scale.

Over the last year, we have continued to improve our infrastructure and platform
to support future growth and additional potential acquisitions. These
improvements included investments in our information technology platforms,
building program management functions to enhance management and communication
with clients and multi-site programs, further enhancing client services and
improving the client experience. We believe the actions taken and investments
made in recent periods form a solid foundation upon which we can continue to
build.

FY 2022 Highlights

Revenue grew to $547.7 million during the fiscal year ended September 30, 2022

("FY 2022") from $89.6 million during the fiscal year ended September 30, 2021 ? ("FY 2021"), driven by a $75.7 million rise in DSA revenue and $382.4 million

of incremental revenue from our RMS business. Growth resulted primarily from


  acquisitions and growing customer demands along with favorable pricing.

Consolidated net loss for the fiscal year ended September 30, 2022 was $(337.3)

million, or (61.6)% of total revenue, compared to consolidated net income of

$10.9 million, or 12.2% of total revenue, in FY 2021. The FY 2022 consolidated ? net loss included a $236.0 million non-cash goodwill impairment charge; $23.0

million of post combination non-cash stock compensation expense relating to the

adoption of the Envigo Equity Plan; and $56.7 million of fair value


  remeasurement of the embedded derivative component of the convertible notes
  issued in September 2021.


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? Book-to-bill ratio was 1.33x for the DSA services business.

? Business Overview

Inotiv is a leading contract research organization dedicated to providing
nonclinical and analytical drug discovery and development services to the
pharmaceutical and medical device industries and selling a range of
research-quality animals and diets to the same industries as well as academia
and government clients. Our products and services focus on bringing new drugs
and medical devices through the discovery and preclinical phases of development,
all while increasing efficiency, improving data, and reducing the cost of
discovering and taking new drugs to market. Inotiv is committed to supporting
discovery and development objectives as well as helping researchers realize the
full potential of their critical research and development projects, all while
working together to build a healthier and safer world. We are dedicated to
practicing high standards of laboratory animal care and welfare.

Through our DSA segment, we support the discovery, nonclinical development and
clinical development needs of researchers and clinicians for primarily small
molecule drug candidates, as well as biotherapeutics and biomedical devices. Our
scientists have skills in analytical instrumentation development, chemistry,
computer software development, histology, pathology, physiology, surgery,
analytical chemistry, drug metabolism, pharmacokinetics, and toxicology to make
the services and products we provide increasingly valuable to our current and
potential clients. Our principal clients are companies whose scientists are
engaged in analytical chemistry, drug safety evaluation, clinical trials, drug
metabolism studies, pharmacokinetics and basic research from small start-up
biotechnology companies to some of the largest global pharmaceutical companies.

Through our RMS segment, we offer access to a wide range of high-quality small
and large research models for basic research and drug discovery and development,
as well as specialized models for specific diseases and therapeutic areas. We
combine deep animal husbandry expertise and expanded access to scientists across
the discovery and preclinical continuum, which reduces nonclinical lead times
and provides enhanced project delivery. In conjunction with our contract
research organization ("CRO") business, we have the ability to run selected
nonclinical studies directly on-site at closely located research model
facilities and access to innovative genetically engineered models and services
solutions. We have long-standing relationships with our principal clients, which
include biopharmaceutical companies, CROs, and academic and government
organizations.

Overview of Financial Information



Revenue for the fiscal year ended September 30, 2022, increased to $547.7
million from $89.6 million in the fiscal year ended September 30, 2021. Acquired
businesses contributed approximately $317.2 million of the increased revenue,
while the remainder was from organic growth.

During the fiscal year ended September 30, 2022, operating loss increased to
$(263.5) million from $(5.6) million in the fiscal year ended September 30,
2021, most significantly driven by a non-cash goodwill impairment charge of
$236.0 million related to our RMS segment and an increase of amortization of
intangible assets to $30.9 million from $1.8 million in the fiscal year ended
September 30, 2021.

Net loss attributable to common shareholders in fiscal year 2022 decreased
to $(337.0) million from net income of $10.9 million in fiscal year 2021 due to
the increase in operating loss described above, as well as $56.7 million of fair
value remeasurement on the embedded derivative component of the convertible
notes issued in September 2021 and $23.0 million of post combination stock
compensation expense relating to the adoption of the Envigo Equity Plan
recognized in connection with the Envigo acquisition.

During fiscal year 2022, our cash flows used in operations was $5.2 million compared to $10.7 million in cash flows provided by operations in fiscal year 2021. Refer to Liquidity and Capital Resources section for analysis of changes.

As of September 30, 2022, the Company had $18.5 million in cash and cash equivalents, a $15.0 million balance on a $15.0 million revolving credit facility, and a $0 balance on a $35.0 million Delay Draw Term Loan ("Additional



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DDTL"). The $35 million Additional DDTL was drawn on October 12, 2022, and a
portion of the proceeds were used to repay the $15.0 million balance on the
revolving credit facility while the remaining was drawn to fund some of the
Company's capital expenditures in 2022 and those planned for 2023. Total debt,
net of debt issuance costs, as of September 30, 2022 was $353.7 million,
including the balance on the revolving credit facility. We were in compliance
with our debt covenants as of September 30, 2022.

For a detailed discussion of our revenue, operating loss, net loss/income and other financial results for the fiscal year ended September 30, 2022, see "Results of Operations" below.

Results of Operations

The following table summarizes the consolidated statement of operations as a percentage of total revenues:

Fiscal Year Ended September 30,


                                                                    2022                               2021
Service revenue                                                          37.1 %                         95.8 %
Product revenue                                                          62.9                            4.2
Total revenue                                                           100.0                          100.0

Cost of services provided 1                                              64.4                           66.7
Cost of products sold 1                                                  75.4                           58.0
Total cost of revenue                                                    71.3                           66.3

Operating expenses                                                       76.8                           39.9

Operating income (loss)                                                (48.1)                          (6.3)

Other expense                                                          (16.3)                           13.1
Loss before income taxes                                               (64.4)                            6.8
Income tax (expense) benefit                                              2.8                            5.3
Consolidated net (loss) income                                         (61.6) %                         12.2 %
Note: Table may not foot due to rounding
1 Percentage of services and products revenue, respectively


Fiscal Year Ended September 30, 2022 Compared to Fiscal year ended September 30, 2021



(dollars in millions)

                    Fiscal Years Ended
                      September 30,
                     2022         2021     $ Change
Services revenue  $    203.0     $  85.8  $    117.2
Products revenue       344.7         3.8       340.9
Total revenue     $    547.7     $  89.6  $    458.1


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DSA

(in millions, except percentages)                                       Fiscal Year Ended
                                                                         September 30,
                                                                      2022            2021         $ Change  % Change
Revenue                                                           $       165.3     $    89.6    $     75.7      84.5 %
Cost of revenue1                                                        (105.9)        (59.4)        (46.5)      78.3
Operating expenses2                                                      (30.9)        (14.2)        (16.7)     117.6
Amortization of intangible assets                                         (6.2)         (1.8)         (4.4)     244.4
Operating income (loss)2, 3, 4                                    $        22.3     $    14.2    $      8.1      57.0 %
Operating income (loss) % of total revenue                                  4.1 %        15.8 %
Operating income (loss) % of segment revenue                               13.5 %        15.8 %
1 Cost of revenue excludes amortization of intangible assets, which is separately stated
2 Operating expenses includes selling, general and administrative and other operating expenses
3 Goodwill impairment losses shown on the consolidated statement of operations only impact the RMS Segment
4 Table may not foot due to rounding


DSA revenue increased $75.7 million for the twelve months ended September 30,
2022 compared to the twelve months ended September 30, 2021. Acquisitions added
$26.1 million of incremental service revenue in excess of fiscal year 2021
service revenue from acquisitions based upon the baseline revenue prior to the
acquisitions. Organic growth generated $49.6 million of DSA incremental service
revenue during the twelve months ended September 30, 2022. Of the $165.3 million
DSA revenue, the acquisitions of HistoTox Labs, Bolder BioPATH, Plato, ILS, and
Protypia generated total separately identifiable revenue in fiscal year 2022 of
$52.4 million. Upon acquisition, Gateway Laboratories and Histion were
integrated into previously-existing entities. Therefore, revenue produced by
these entities is not separately identifiable.

In the fiscal year ended September 30, 2022, we experienced an increase in study
cancellations in our DSA segment due primarily to compounds, which were not yet
available for testing, and due to delayed studies as a result of lack of
funding. When contracts are terminated, we are generally able to recover, at
minimum, our invested costs. Despite an increased trend in cancellations, our
flexibility has enabled us to replace the cancelled or postponed studies with
studies from other clients.

DSA operating income increased by $8.1 million in fiscal year 2022 compared to
fiscal year 2021 primarily due to higher revenues as a result of acquisitions,
favorable pricing and our investments in the DSA business designed to increase
margins and capacity to enhance our ability to meet growing customer demand.
Additionally, operating expenses, including selling, general and administrative
and other operating expense, increased primarily due to increases in general and
administrative expenses from the overall growth in the business as a result of
acquisitions and internal growth, which included an increase of $4.2 million in
startup costs compared to fiscal year 2021. Amortization of intangibles
increased year over year primarily as a result of additional acquired intangible
assets since September 30, 2021, as well as a full year impact of intangible
assets acquired during fiscal year 2021.

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RMS

(in millions, except percentages)                                                       Fiscal Year Ended
                                                                                          September 30,
                                                                                               2022
Revenue                                                                           $                      382.4
Cost of revenue1                                                                                       (284.6)
Operating expenses2                                                                                     (26.4)

Amortization of intangible assets                                                                       (24.7)
Goodwill impairment loss3                                                                              (236.0)
Operating income (loss)2, 3, 4                                                    $                    (189.3)
Operating income (loss) % of total revenue                                                              (34.6) %
Operating income (loss) % of segment revenue                                                            (49.5) %
Operating loss % of segment revenue
1 Cost of revenue excludes amortization of intangible assets, which is separately stated
2 Operating expenses includes selling, general and administrative and other operating expenses
3 Goodwill impairment losses shown on the consolidated statement of operations only impact the RMS Segment
4 Table may not foot due to rounding


RMS revenue was $382.4 million for the twelve months ended September 30, 2022.
The acquisitions of Envigo, RSI and OBRC added $291.1 million of incremental
acquisition revenue based upon the baseline revenue prior to the acquisitions,
and internal growth generated $91.3 million of additional revenue in the RMS
segment during fiscal year 2022. RMS revenue in the twelve months ended
September 30, 2022 reflected one partial and three full quarters of contribution
from Envigo, which was acquired on November 5, 2021, three full quarters of
contribution from RSI, which was acquired on December 29, 2021, and one partial
and two full quarters of contribution from OBRC, which was acquired on January
27, 2022.

RMS operating loss was $189.3 million in fiscal year 2022. The loss includes
non-cash charges for goodwill impairment of $236.0 million, $24.7 million
intangible amortization related to intangible assets acquired through the
acquisitions of Envigo, RSI and OBRC, $11.1 million of depreciation expense and
$10.2 million amortization of inventory step-up related to inventory acquired
through the acquisitions of Envigo and OBRC. The sustained reduction in our
stock price caused the Company to evaluate the carrying value of our goodwill as
of fiscal year end. As a result of our impairment assessment, the Company
determined that the carrying amount of goodwill attributed to our RMS segment
was in excess of its fair value. Additionally, the RMS segment results include
restructuring costs of $8.6 million related to the closure of our Dublin
facility and Cumberland facility

Unallocated Corporate


(in millions, except percentages)                        Fiscal Year Ended

                                                           September 30,
                                                      2022             2021                                   $ Change  % Change
Operating expenses1                                     (96.4)           (19.8)                                 (76.6)     386.9
Operating loss2                                   $     (96.4)     $     (19.8)                             $   (76.6)     386.9 %
Operating loss % of total revenue                       (17.6) %         (22.1) %
1 Operating expenses includes selling, general and administrative and other operating expenses
2 Table may not foot due to rounding


Unallocated corporate costs consist of selling and general and administrative
and other operating expenses that are not directly related or allocated to the
reportable segments. The increase in unallocated corporate costs to $96.4
million, compared to $19.8 million in fiscal year 2021, was primarily related to
increased costs associated with additional headcount, recruiting and relocation
expense, higher compensation expense, acquisition and integration costs and

post

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combination stock compensation expense relating to the adoption of the Envigo Equity Plan recognized in connection with the Envigo acquisition of $23.0 million.

Other Expense



Other (expense) income decreased by $73.9 million for fiscal year 2022 compared
to fiscal year 2021. The decrease is primarily due to the loss of $(56.7)
million in fiscal year 2022 of fair value remeasurement of the embedded
derivative component of the convertible notes issued in September 2021 compared
to the gain of $8.4 million in fiscal year 2021 of fair value remeasurement of
the embedded derivative component of the convertible notes issued in September
2021. For additional information, see "Capital Resources - Convertible Senior
Notes" below. There was also an increase in interest expense of $28.0 million in
fiscal year 2022 compared to fiscal year 2021 as a result of the increased debt
balance as a result of the additional debt obtained in connection with the
acquisitions of Envigo, ILS and OBRC.

Income Taxes


Our effective income tax rates for fiscal year 2022 and 2021 were 4.3% and
(78.0)%, respectively. The benefit recorded for each period was $15.2 million
and $4.8 million, respectively. The benefit from income taxes for fiscal year
2022 primarily relates to deferred tax benefits on the pre-tax loss, off set
primarily by the impact on tax expense of certain non-deductible permanent book
to tax differences related to goodwill impairment, loss on fair value
remeasurement of the embedded derivative component of the convertible notes,
compensation, and other permanent items. The benefit from income taxes for
fiscal year 2021 related primarily to a change in valuation allowance resulting
from the Bolder BioPATH acquisition on May 3, 2021.

Consolidated net (loss) income


As a result of the above described factors, we had a consolidated net loss of
$337.3 million for the twelve months ended September 30, 2022 as compared to
consolidated net income of $10.9 million during the twelve months ended
September 30, 2021.

Liquidity and Capital Resources

As of September 30, 2022, the Company has cash and cash equivalents of approximately $18.5 million.


The Company experienced cash used from operating activities in fiscal 2022 which
was primarily driven by an increase in working capital, more specifically an
increase in inventory and prepaid deposits.  These increases in working capital
are driven by the timing of prepaid deposits for future NHP shipments, the
shipment of NHPs and the collection of cash as it relates to the shipments to
customers. The Company also announced the closure of two sites, Cumberland and
Dublin, in fiscal 2022 which required additional operating cash outflows during
fiscal 2022.  Those sites were exited in September and December 2022,
respectively.  As such, the resulting operating efficiencies from those site
closures will benefit fiscal 2023, as well as savings of the additional one-time
cash outflows previously incurred to close the site.  Additionally, the Company
had $16.1 million of acquisition and integration costs incurred in fiscal 2022
as a result of the seven acquisitions that it closed during fiscal 2022.

The Company currently does not have any significant acquisitions planned in fiscal 2023. For additional information regarding the Company's ongoing liquidity assessment, see Events Subsequent to September 30, 2022 - Liquidity section below.



Management believes its existing cash and cash equivalents, together with cash
generated from operations, will be sufficient to fund its operations, satisfy
its obligations, including cash outflows for planned targeted capital
expenditures, and comply with minimum liquidity and financial covenant
requirements under its debt covenants related to borrowings pursuant to its
Senior Term Loan for at least the next twelve months. In order to achieve net
positive operating cash flows, the Company believes it will need to continue to
sell a majority of its existing Cambodian NHP inventory. See Note 7- Debt for
further information about our existing credit facilities and requirements under
its debt covenants. The

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Company's liquidity needs thereafter will depend, among other things, on the
timing of NHP shipments, its ability to import NHPs and its ability to generate
cash from operations.

Comparative Cash Flow Analysis



As of September 30, 2022, we had cash and cash equivalents, including restricted
cash, of $19.0 million compared to $156.9 million as of September 30, 2021. As
of September 30, 2022, we had a $15 million balance on our revolving credit
facility. In addition, as of September 30, 2021, we had $5.0 million available
on our general line of credit and $1.3 million available on our capex line of
credit.

Net cash used by operating activities was $(5.2) million for the year ended
September 30, 2022, compared to net cash provided by operating activities of
$10.7 million for the year ended September 30, 2021. Contributing factors to our
cash used by operations for fiscal year ended September 30, 2022 were
consolidated net loss of $(337.3) million, noncash charges of $236.0 million for
goodwill impairment loss, $56.7 million for loss on fair value remeasurement of
embedded derivative, $49.3 million for depreciation and amortization, $24.2
million for stock compensation expense, $10.2 million for amortization of
inventory fair value step-up, $5.3 million of non-cash interest and accretion
expense, and $8.5 million for other non-cash operating charges, partially offset
by $(17.8) million for changes in deferred taxes and $(40.3) million for changes
in operating assets and liabilities. Refer to the Statement of Cash Flows within
this Report for further details of net cash used by operating activities.

Investing activities used $(333.7) million for the fiscal year ended
September 30, 2022 compared to net cash used by investing activities of $(54.1)
million for the fiscal year ended September 30, 2021. Contributing factors to
our cash used by investing activities for fiscal year ended were capital
expenditures of $(36.3) million, $0.3 million of proceeds from the sale of
equipment and $(297.7) million of cash paid in acquisitions, net of cash
acquired.

Capital expenditures for the DSA segment relate to infrastructure, equipment and
facility upgrades to provide expanded capacity for our Boulder and Morrisville
facilities, the buildout of our new Rockville facility to support
biotherapeutics and genetic toxicology growth. Further, we made significant
investments in upgrading facilities and equipment across the facilities that
serve the RMS segment in order to implement planned and proposed site
optimizations and enhance animal welfare.

Financing activities provided $203.2 million during the fiscal year ended
September 30, 2022 compared to $198.8 million during the fiscal year ended
September 30, 2021. Contributing factors included $240.0 million in borrowings
on senior term notes and delayed draw term loans, $34.0 million in borrowings on
the revolving credit facility, partially offset by $(36.8) million in payments
of long-term debt related to the extinguishment of the FIB Term Loans, $(19.0)
million in payments on the revolving credit facility, $(10.1) million in
payments of debt issuance costs, $(2.2) million in payments on promissory notes,
$(1.8) million in payments on senior term notes and delayed draw term loans and
$(1.1) of other financing activities, net.

Capital Resources

Credit Facility



On November 5, 2021, the Company, certain of the subsidiaries of the Company
(the "Subsidiary Guarantors"), the lenders party thereto, and Jefferies Finance
LLC, as administrative agent, entered into a Credit Agreement (the "Credit
Agreement"). The Credit Agreement provides for a term loan facility in the
original principal amount of $165.0 million, a delayed draw term loan facility
in the original principal amount of $35.0 million (available to be drawn up to
18 months from the date of the Credit Agreement), and a revolving credit
facility in the original principal amount of $15.0 million. On November 5, 2021,
the Company borrowed the full amount of the term loan facility, but did not
borrow any amounts on the delayed draw term loan facility or the revolving
credit facility.

Prior to the Second Amendment and Third Amendment (as defined below), the
Company may elect to borrow on each of the loan facilities at either an adjusted
LIBOR rate of interest or an adjusted prime rate of interest. Adjusted LIBOR
rate loans shall accrue interest at an annual rate equal to the LIBOR rate plus
a margin of between 6.00% and 6.50%,

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depending on the Company's then current Secured Leverage Ratio (as defined in
the Credit Agreement). The LIBOR rate must be a minimum of 1.00%. The initial
adjusted LIBOR rate of interest is the LIBOR rate plus 6.25%. Adjusted prime
rate loans shall accrue interest at an annual rate equal to the prime rate plus
a margin of between 5.00% and 5.50%, depending on the Company's then current
Secured Leverage Ratio. The initial adjusted prime rate of interest is the prime
rate plus 5.25%. Interest expense was accrued at an effective rate of 9.83%
through September 30, 2022.

The Company must pay (i) a fee based on a percentage per annum equal to 0.50% on
the average daily undrawn portion of the commitments in respect of the revolving
credit facility and (ii) a fee based on a percentage per annum equal to 1.00% on
the average daily undrawn portion of the commitments in respect of the delayed
draw loan facility. In each case, such fee shall be paid quarterly in arrears.

Each of the term loan facility and delayed draw term loan facility require
annual principal payments in an amount equal to 1.0% of their respective
original principal amounts. The Company shall also repay the term loan facility
on an annual basis in an amount equal to a percentage of its Excess Cash Flow
(as defined in the Credit Agreement), which percentage will be determined by its
then current Secured Leverage Ratio. Each of the loan facilities may be repaid
at any time with premium or penalty.

The Company is required to maintain an initial Secured Leverage Ratio of not
more than 4.25 to 1.00. The maximum permitted Secured Leverage Ratio shall
reduce to 3.75 to 1.00 beginning with the Company's fiscal quarter ending
September 30, 2023 and to 3.00 to 1.00 beginning with the Company's fiscal
quarter ending March 31, 2025. The Company is required to maintain a minimum
Fixed Charge Coverage Ratio (as defined in the Credit Agreement), which ratio
shall be 1.00 to 1.00 during the first year of the Credit Agreement and shall be
1.10 to 1.00 from and after the Credit Agreement's first anniversary.

Each of the loan facilities is secured by all assets (other than certain excluded assets) of the Company and each of the Subsidiary Guarantors. Repayment of each of the loan facilities is guaranteed by each of the Subsidiary Guarantors.



Utilizing proceeds from the Credit Agreement on November 5, 2021, the Company
repaid all indebtedness and terminated the credit agreement related to the First
Internet Bank of Indiana ("FIB") credit facility and recognized an $0.9 million
loss on debt extinguishment.

On January 7, 2022, the Company drew $35.0 million on the delayed draw term loan
facility. The delayed draw term loan facility in the original principal amount
of $35.0 million is referred to herein as the "Initial DDTL". Amounts
outstanding under the Initial DDTL accrue interest at an annual rate equal to
the LIBOR rate plus a margin of between 6.00% and 6.50%, depending on the
Company's then current Secured Leverage Ratio (as defined in the Credit
Agreement). The initial adjusted LIBOR rate of interest is the LIBOR rate of
1.00% plus 6.25% for a total rate of 7.25%. Interest expense was accrued at an
effective rate of 9.89% through September 30, 2022.

As of September 30, 2022, the Company had an outstanding balance of $15.0 million on the revolving credit facility.

First Amendment to Credit Agreement


On January 27, 2022, the Company, Subsidiary Guarantors, the lenders party
thereto, and Jefferies Finance LLC, as administrative agent, entered into a
First Amendment (the "Amendment") to the existing Credit Agreement. The
Amendment provides for, among other things, an increase to the existing term
loan facility in the amount of $40.0 million (the "Incremental Term Loans") and
a new delayed draw term loan facility in the original principal amount of $35.0
million, which amount is available to be drawn up to 24 months from the date of
the Amendment (the "DDTL"). The Incremental Term Loans and any amounts borrowed
under the DDTL are referred to herein as the "Additional Term Loans". On
January 27, 2022, the Company borrowed the full amount of the Incremental Term
Loans, but did not borrow any amounts under the DDTL.

Amounts outstanding under the Additional Term Loans will accrue interest at an
annual rate equal to the LIBOR rate plus a margin of between 6.00% and 6.50%,
depending on the Company's then current Secured Leverage Ratio (as

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defined in the Credit Agreement). The initial adjusted LIBOR rate of interest is
the LIBOR rate of 1.00% plus 6.25% for a total rate of 7.25%. Actual interest
accrued at 9.83% through September 30, 2022. .

The Additional Term Loans require annual principal payments in an amount equal
to 1.0% of the original principal amount. Voluntary prepayments of the
Additional Term Loans will be subject to a 2% prepayment premium if made on or
prior to November 5, 2022 and a 1% prepayment premium if made on or prior to
November 5, 2023. Voluntary prepayments made after November 5, 2023 are not
subject to a prepayment premium.

Each of the Additional Term Loans require annual principal payments in an amount
equal to 1.0% of its respective original principal amounts. The Company shall
also repay the term loans on an annual basis in an amount equal to a percentage
of its Excess Cash Flow (as defined in the Credit Agreement), which percentage
will be determined by its then current Secured Leverage Ratio.

The Additional Term Loans are secured by all assets (other than certain excluded
assets) of the Company and each of the Subsidiary Guarantors. Repayment of the
Additional Term Loans is guaranteed by each of the Subsidiary Guarantors.

The Additional Term Loans will mature on November 5, 2026.



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Long term debt as of September 30, 2022 and September 30, 2021 is detailed in
the table below.

                                                                                 As of:
(in millions)                                                   September 30, 2022     September 30, 2021
FIB Term Loans                                                 $                  -    $              36.2
Seller Note - Bolder BioPath                                                    0.8                    1.5
Seller Note - Smithers Avanza                                                     -                    0.3
Seller Note - Preclinical Research Services                                     0.6                    0.7
Seller Note - Plato BioPharma                                                   1.5                      -
Seller Payable - Orient BioResource Center                                 

    3.5                      -
Seller Note - Histion                                                           0.4                      -
Seller Note - Protypia                                                          0.6                      -

Economic Injury Disaster Loan                                                   0.1                      -
Convertible Senior Notes                                                      105.0                  131.7
Term Loan Facility, Initial DDTL and Incremental Term Loans                

  238.2                      -
                                                                              350.7                  170.3
Less: Current portion                                                         (8.0)                  (9.7)

Less: Debt issue costs not amortized                                         (12.0)                  (6.5)
Total Long-term debt                                           $              330.7    $             154.1

Note: Table may not foot due to rounding

Refer to Note 7 - Debt for the combined aggregate amount of maturities over the next five years.



Acquisition-related Debt

In addition to the indebtedness under the Credit Agreement, certain of the
Company's subsidiaries have issued unsecured notes as partial payment of the
purchase prices of certain acquisitions as described herein. Each of these notes
is subordinated to the indebtedness under the Credit Agreement.

As part of the acquisition of Plato, which is a part of the Company's Inotiv
Boulder subsidiary, Inotiv Boulder, LLC, the Company issued unsecured
subordinated promissory notes payable to the former shareholders of Plato in an
aggregate principal amount of $3.0 million. The promissory notes bear interest
at a rate of 4.5% per annum, with monthly payments of principal and interest and
a maturity date of June 1, 2023.

As part of the acquisition of OBRC, the Company agreed to leave in place a
payable owed by OBRC to the seller in the amount of $3.7 million, which the
Company determined to have a fair value of $3.3 million as of January 27, 2022.
The payable does not bear interest and is required to be paid to seller on the
date that is 18 months after the closing date of January 27, 2022. The Company
has the right to set off against the payable any amounts that become payable by
the seller on account of indemnification obligations under the purchase
agreement.

As part of the acquisition of Histion, LLC ("Histion") which is a part of the
Company's subsidiary, Bronco Research Services, LLC, the Company issued
unsecured subordinated promissory notes payable to the former shareholders of
Histion in an aggregate principal amount of $0.4 million. The promissory notes
bear interest at a rate of 4.5% per annum, with monthly payments of principal
and interest and a maturity date of April 1, 2025.

As part of the acquisition of Protypia, Inc. ("Protypia"), the Company issued
unsecured subordinated promissory notes payable to the former shareholders of
Protypia in an aggregate principal amount of $0.6 million. The promissory notes
bear interest at a rate of 4.5% per annum, with monthly payments of principal
and interest and a maturity date of January 7, 2024.

Convertible Senior Notes



On September 27, 2021, the Company issued $140.0 million principal amount of its
3.25% Convertible Senior Notes due 2027 (the "Notes"). The Notes were issued
pursuant to, and are governed by, an indenture, dated as of September

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27, 2021, among the Company, the Company's wholly owned subsidiary, BAS
Evansville, Inc., as guarantor (the "Guarantor"), and U.S. Bank National
Association, as trustee (the "Indenture"). Pursuant to the purchase agreement
between the Company and the initial purchaser of the Notes, the Company granted
the initial purchaser an option to purchase, for settlement within a period of
13 days from, and including, the date the Notes were first issued, up to an
additional $15.0 million principal amount of the Notes. The Notes issued on
September 27, 2021 included $15,000 principal amount of the Notes issued
pursuant to the full exercise by the initial purchaser of such option. The
Company used the net proceeds from the offering of the Notes, together with
borrowings under a new senior secured term loan facility, to fund the cash
portion of the purchase price of the Envigo acquisition and related fees and
expenses.

The Notes are the Company's senior, unsecured obligations and are (i) equal in
right of payment with the Company's existing and future senior, unsecured
indebtedness; (ii) senior in right of payment to the Company's existing and
future indebtedness that is expressly subordinated to the Notes; (iii)
effectively subordinated to the Company's existing and future secured
indebtedness, to the extent of the value of the collateral securing that
indebtedness; and (iv) structurally subordinated to all existing and future
indebtedness and other liabilities, including trade payables, and (to the extent
the Company is not a holder thereof) preferred equity, if any, of the Company's
non-guarantor subsidiaries. The Notes are fully and unconditionally guaranteed,
on a senior, unsecured basis, by the Guarantor.

The Notes accrue interest at a rate of 3.25% per annum, payable semi-annually in
arrears on April 15 and October 15 of each year, beginning on April 15, 2022.
The Notes will mature on October 15, 2027, unless earlier repurchased, redeemed
or converted. Before April 15, 2027, noteholders have the right to convert their
Notes only upon the occurrence of certain events. From and after April 15, 2027,
noteholders may convert their Notes at any time at their election until the
close of business on the scheduled trading day immediately before the maturity
date. The Company will settle conversions by paying or delivering, as
applicable, cash, its common shares or a combination of cash and its common
shares, at the Company's election. The initial conversion rate is 21.7162 common
shares per $1 thousand principal amount of Notes, which represents an initial
conversion price of approximately $46.05 per common share. The conversion rate
and conversion price are subject to customary adjustments upon the occurrence of
certain events. In addition, if certain corporate events that constitute a
"Make-Whole Fundamental Change" (as defined in the Indenture) occur, then the
conversion rate will, in certain circumstances, be increased for a specified
period of time.

As of September 30, 2022 and 2021, there are $5,060 and $5,909 in unamortized
debt issuance costs related to the Convertible Senior Notes, respectively. For
the year ended September 30, 2022, the total interest expense was $10,624,
including coupon interest expense of $4,613, accretion expense of $5,162, and
the amortization of debt discount and issuance costs of $849.

The Notes are redeemable, in whole and not in part, at the Company's option at
any time on or after October 15, 2024 and on or before the 40th scheduled
trading day immediately before the maturity date, but only if the last reported
sale price per common share of the Company exceeds 130% of the conversion price
on (i) each of at least 20 trading days, whether or not consecutive, during the
30 consecutive trading days ending on, and including, the trading day
immediately before the date the Company sends the related redemption notice; and
(ii) the trading day immediately before the date the Company sends such notice.
The redemption price is a cash amount equal to the principal amount of the Notes
to be redeemed, plus accrued and unpaid interest, if any, to, but excluding, the
redemption date. In addition, calling the Notes for redemption pursuant to the
provisions described in this paragraph will constitute a Make-Whole Fundamental
Change, which will result in an increase to the conversion rate in certain
circumstances for a specified period of time.

If certain corporate events that constitute a "Fundamental Change" (as defined
in the Indenture) occur, then noteholders may require the Company to repurchase
their Notes at a cash repurchase price equal to the principal amount of the
Notes to be repurchased, plus accrued and unpaid interest, if any, to, but
excluding, the Fundamental Change repurchase date. The definition of Fundamental
Change includes certain business combination transactions involving the Company
and certain de-listing events with respect to the Company's common shares.

The Notes have customary provisions relating to the occurrence of "Events of
Default" (as defined in the Indenture), which include the following: (i) certain
payment defaults on the Notes (which, in the case of a default in the payment of
interest on the Notes, are subject to a 30-day cure period); (ii) the Company's
failure to send certain notices under the Indenture within specified periods of
time; (iii) the failure by the Company or the Guarantor to comply with

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certain covenants in the Indenture relating to the ability of the Company or the
Guarantor to consolidate with or merge with or into, or sell, lease or otherwise
transfer, in one transaction or a series of transactions, all or substantially
all of the assets of the Company or the Guarantor, as applicable, and its
subsidiaries, taken as a whole, to another person; (iv) a default by the Company
or the Guarantor in its other obligations or agreements under the Indenture or
the Notes if such default is not cured or waived within 60 days after notice is
given in accordance with the Indenture; (v) certain defaults by the Company, the
Guarantor or any of their respective subsidiaries with respect to indebtedness
for borrowed money of at least $20.0 million; (vi) the rendering of certain
judgments against the Company, the Guarantor or any of their respective
subsidiaries for the payment of at least $20.0 million, where such judgments are
not discharged or stayed within 60 days after the date on which the right to
appeal has expired or on which all rights to appeal have been extinguished;
(vii) certain events of bankruptcy, insolvency and reorganization involving the
Company, the Guarantor or any of their respective significant subsidiaries; and
(viii) the guarantee of the Notes ceases to be in full force and effect (except
as permitted by the Indenture) or the Guarantor denies or disaffirms its
obligations under its guarantee of the Notes.

If an Event of Default involving bankruptcy, insolvency or reorganization events
with respect to the Company or the Guarantor (and not solely with respect to a
significant subsidiary of the Company or the Guarantor) occurs, then the
principal amount of, and all accrued and unpaid interest on, all of the Notes
then outstanding will immediately become due and payable without any further
action or notice by any person. If any other Event of Default occurs and is
continuing, then, the trustee, by notice to the Company, or noteholders of at
least 25% of the aggregate principal amount of Notes then outstanding, by notice
to the Company and the trustee, may declare the principal amount of, and all
accrued and unpaid interest on, all of the Notes then outstanding to become due
and payable immediately. However, notwithstanding the foregoing, the Company may
elect, at its option, that the sole remedy for an Event of Default relating to
certain failures by the Company to comply with certain reporting covenants in
the Indenture consists exclusively of the right of the noteholders to receive
special interest on the Notes for up to 180 days at a specified rate per annum
not exceeding 0.50% on the principal amount of the Notes.

In accordance with ASC 815, at issuance, the Company evaluated the convertible
feature of the Notes and determined it was required to be bifurcated as an
embedded derivative and did not qualify for equity classification. The
convertible feature of the Notes is subject to fair value remeasurement as of
each balance sheet date or until it meets equity classification requirements and
is valued utilizing Level 3 inputs as described below. The discount resulting
from the initial fair value of the embedded derivative will be amortized to
interest expense using the effective interest method. Non-cash interest expense
during the period primarily related to this discount.

In the first quarter of 2022, the Company adopted Accounting Standards Update
("ASU") ASU 2020-06, Debt - Debt with Conversion and Other Options (Subtopic
470-20) and Derivatives and Hedging - Contracts in Entity's Own Equity (Subtopic
815-40) ("ASU 2020-06"). The update simplifies the accounting for convertible
debt instruments and convertible preferred shares by reducing the number of
accounting models and limiting the number of embedded conversion features
separately recognized from the primary contract. As a result of the approval of
the increase in authorized shares on November 4, 2021 (see Note 13 - Equity),
the Note conversion rights met all equity classification criteria in ASC 815. As
a result, the derivative liability was remeasured as of November 4, 2021 and
reclassified out of long-term liabilities and into additional paid-in capital.

Based upon the above, the Company remeasured the fair value of the embedded
derivative as of November 4, 2021 which resulted in a fair value measurement of
$88.6 million and a loss on remeasurement included in other income (loss) for
the twelve months ended September 30, 2022 of $56.7 million. The embedded
derivative liability of $78.3 million was then reclassified to additional
paid-in capital in accordance with ASC 815.

Inflation

We do not believe that inflation has had a material adverse effect on our business, operations or financial condition.

Events Subsequent to September 30, 2022



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On October 12, 2022, the Company borrowed the full amount of its existing $35.0 ? million delayed draw term loan facility under its credit agreement. A portion

of the proceeds was used to repay the $15.0 million balance on the Company's

revolving credit facility.

On November 16, 2022, the Company became aware that the U.S. Attorney's Office

for the Southern District of Florida has criminally charged employees of the

principal supplier of NHPs to the Company, along with two Cambodian government

officials, with conspiring to illegally import NHPs into the United States from

December 2017 through January 2022 and in connection with seven specific

imports between July 2018 and December 2021. Due to the allegations contained ? in the indictment involving the supplier and the Cambodian government

officials, the Company believed that it was prudent, at the time and continuing

as of the date of this release, to refrain from selling or delivering any of

its Cambodian NHPs held in the U.S. until the Company's staff and external

experts can evaluate what additionally could be done to satisfy itself that the


  NHPs in inventory from Cambodia can be reasonably determined to be
  purpose-bred.

On November 29, 2022, the Company announced additional site consolidation plans ? in the U.S. and its intent to consult with employee representatives for a

proposed consolidation of certain European and U.K. sites and provided an

update on site optimization plans in process.

On December 8, 2022, the Company announced the opening of the second phase of ? its lab facility in Rockville, MD, the scheduled opening date of January 2023

for its pathology campus and training center in Kalamazoo, MI, and the opening

and occupancy of the site expansion at its facility in Boulder, CO.

On December 12, 2022, the Company issued a press release discussing the impact ? of the Cambodian NHPs matters on its business, as well as the Company's

perspective on the impact to the industry.

? On December 29, 2022, the Company entered into a Second Amendment to the Credit

Agreement. Refer to Note 18 - Subsequent Events for further detail.

? On January 9, 2023, the Company entered into a Third Amendment to the Credit

Agreement. Refer to Note 18 - Subsequent Events for further detail.

Temporarily Suspended or Limited Operations



On November 16, 2022, the Company became aware that the U.S. Attorney's Office
for the Southern District of Florida ("USAO-SDFL") had criminally charged
employees of the principal supplier of NHPs to the Company, along with two
Cambodian government officials, with conspiring to illegally import NHPs into
the U.S. from December 2017 through January 2022 and in connection with seven
specific imports between July 2018 and December 2021. Also as previously
disclosed, two of the Company's subsidiaries, Orient BioResource Center and
Envigo Global Services, Inc., companies acquired by the Company on January 27,
2022 and November 5, 2021, respectively, had received grand jury subpoenas from
USAO-SDFL requiring the production of documents and information related to their
importation of NHPs into the U.S. The Company has been fully cooperating, and
will continue to cooperate, with USAO-SDFL.

The Company has not been directed to refrain from selling the Cambodian NHPs in
its possession in the U.S. However, due to the allegations contained in the
indictment involving the Supplier and the Cambodian government officials, the
Company believed that it was prudent, at the time and through the date of its
Annual Report on Form 10-K, to refrain from selling or delivering any of its
Cambodian NHPs held in the U.S. until the Company's staff and external experts
can evaluate what additionally could be done to satisfy itself that the NHPs in
inventory from Cambodia can be reasonably determined to be purpose-bred.
Historically, the Company has relied on the Convention on International Trade in
Endangered Species of Wild Fauna and Flora ("CITES") documentation and related
processes and procedures, including release of each import by U.S. Fish and
Wildlife Service. The Company has continued to sell NHPs from other suppliers.
The Company has shipments of its Cambodian NHP inventory scheduled, which will
be resumed once existing inventory can be reasonably determined to be
purpose-bred.

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Of the Company's total revenue of $547.7 million in fiscal 2022, approximately
$140 million was from NHPs that it had imported from Cambodia. Refer to the
Liquidity section below and Note 18 - Subsequent Events for further discussion
of anticipated impacts.

Liquidity



As of September 30, 2022, the Company has cash and cash equivalents of
approximately $18.5 million. The November 16, 2022 event and subsequent decision
to refrain from selling or delivering Cambodian NHPs held in the U.S., triggered
a material adverse event clause in our Credit Agreement discussed in Note 7 to
these consolidated financial statements resulting in, among other things a
limitation of our ability to draw on our revolving credit facility. The loss of
access to our revolving credit facility and reduced liquidity resulting from the
decision to refrain from selling Cambodian NHPs held in the U.S. resulted in
reduced forecasted liquidity. As a result of these events, we took steps to
improve our liquidity, which included negotiating an amendment to our Credit
Agreement to reinstate our ability to borrow under our revolving credit
facility. Without the amendment, the Company was at risk of not having the
revolving credit facility available. During the three months ended December 31,
2022, the Company announced the completion of the closure of the Cumberland and
Dublin, Virginia facilities and announced further intended site optimizations
plans for 2023 and 2024, including two U.S. facilities, which have been
approved, and two European facilities, which are subject to approval. Further,
the Company has communicated price increases that will begin in January 2023.
The Company also took steps in reducing our 2023 budgeted capital expenditures
and certain forecasted expenses, including a reduction of nonessential travel
and employee-related expenses among other efficiency-based reductions. As a
result, the Company believes its existing cash and cash equivalents, together
with cash generated from operations, will be sufficient to fund its operations,
satisfy its obligations, including cash outflows for planned targeted capital
expenditures, and comply with minimum liquidity and financial covenant
requirements under its debt covenants related to borrowings pursuant to its
Credit Agreement for at least the next twelve months. In order to achieve the
forecasted operating cash flows, the Company believes it will need to begin
shipping its existing Cambodian NHP inventory. See Note 7- Debt and Note 18 -
Subsequent Events for further information about the Company's existing credit
facilities and requirements under its debt covenants. The Company's liquidity
needs and compliance with covenants thereafter will depend, among other things,
on the timing of NHP shipments and its ability to generate cash from operations.

Critical Accounting Policies and Significant Judgments and Estimates


"Management's Discussion and Analysis of Financial Condition and Results of
Operations" and "Liquidity and Capital Resources" is based upon our consolidated
financial statements prepared in accordance with generally accepted accounting
principles in the United States (U.S.). The preparation of these financial
statements requires us to make certain estimates and assumptions that may affect
the reported amounts of assets and liabilities, the reported amounts of revenues
and expenses during the reported periods and related disclosures. These
estimates and assumptions are monitored and analyzed by us for changes in facts
and circumstances, and material changes in these estimates could occur in the
future. We base our estimates on our historical experience, trends in the
industry, and various other factors that are believed to be reasonable under the
circumstances. Actual results may differ from our estimates under different
assumptions or conditions.

We believe that the application of our accounting policies, each of which
require significant judgments and estimates on the part of management, are the
most critical to aid in fully understanding and evaluating our reported
financial results. Our significant accounting policies are more fully described
in Note 2 - Summary of Significant Accounting Policies to our consolidated
financial statements contained in Item 8 - Financial Statements and
Supplementary Data in this Annual Report on Form 10-K.

We believe the following represent our critical accounting policies and estimates used in the preparation of our financial statements:



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Revenue Recognition

In accordance with Accounting Standards Codification ("ASC") 606, the Company
disaggregates its revenue from clients into two revenue streams, service revenue
and product revenue. At contract inception the Company assesses the services
promised in the contract with the clients to identify performance obligations in
the arrangements. In accordance with ASC 606, the Company determines appropriate
revenue recognition by completing the following steps: (i) identifiying the
contract(s) with a customer; (ii) identifying the performance obligations in the
contract; (iii) determining the transaction price; (iv) allocating of the
transaction price to the performance obligations in the contract; and (v)
recognizing revenue when or as the Company satisfies a performance obligation.

Service revenue

DSA

The Company enters into contracts with clients to provide drug discovery and
development services. The Company also offers archive storage services to its
clients. The Company's fixed fee arrangements may involve nonclinical research
services (e.g., toxicology, pathology, pharmacology), bioanalytical, and
pharmaceutical method development and validation, nonclinical research services
and the analysis of bioanalytical and pharmaceutical samples. For bioanalytical
and pharmaceutical method validation services and nonclinical research services,
revenue is recognized over time using the input method based on the ratio of
direct costs incurred to total estimated direct costs. For contracts that
involve in-life study conduct, method development or the analysis of
bioanalytical and pharmaceutical samples, revenue is recognized over time when
samples are analyzed or when services are performed. In determining the
appropriate amount of revenue to recognize over time, the Company forecasts
remaining costs related to the contracts with customers. In order to forecast
the remaining costs, the Company reviews the billings compared to original cost
estimates, meets with project managers and updates cost estimates in relation to
any scope changes requested by the client.

The Company generally bills for services on a milestone basis. These contracts
represent a single performance obligation and due to the Company's right to
payment for work performed, revenue is recognized over time. Research services
contract fees received upon acceptance are deferred until earned and classified
within fees invoiced in advance on the consolidated balance sheets. Unbilled
revenues represent revenues earned under contracts in advance of billings and
classified within trade receivables and contract assets on the consolidated
balance sheets.

Our service contracts typically establish an fixed fee to be paid for identified
services. In most cases, some percentage of the contract costs is paid in
advance. While we are performing a contract, clients often adjust the scope of
services to be provided based on interim project results. Fees are adjusted
accordingly. Generally, our fee-for-service contracts are terminable by the
client upon written notice of 30 days or less for a variety of reasons,
including the client's decision to forego a particular study, the failure of
product prototypes to satisfy safety requirements, and unexpected or undesired
results of product testing. Cancellation or delay of ongoing contracts may
result in fluctuations in our quarterly and annual results. We are generally
able to recover, at minimum, our invested costs plus an appropriate margin

when
contracts are terminated.

RMS

The Company provides GEMS, which includes the performance of contract breeding
and other services associated with genetically engineered models, client-owned
animal colony care, and health monitoring and diagnostics services related to
research models. For contracts that involve creation of a specific type of
animal, revenue is recognized over time with each milestone as a separate
performance obligation. The Company is due payment for work performed even if
subsequent milestones are unable to be met. Contract breeding revenue and
client-owned animal colony care revenue are recognized over time and are billed
as per diems. Health monitoring revenue and diagnostic services revenue are
recognized once the service is performed.

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Product revenue

DSA

DSA product revenue includes internally-manufactured scientific instruments for
life sciences research and the related software for use by pharmaceutical
companies, universities, government research centers and medical research
institutions under the Company's BASi product line. These products can be sold
to multiple clients and have alternative use. Both the transaction sales price
and shipping terms are agreed upon in the client order. For these products, all
revenue is recognized at a point in time, generally when title of the product
and control is transferred to the client based upon shipping terms. These
arrangements typically include only one performance obligation.

RMS



Product revenue included research models, diets and bedding and bioproducts.
Research models revenue represents the commercial production and sale of
research models, principally purpose-bred rats and mice for use by researchers,
and large-animal models. Diets and bedding revenue represents laboratory animal
diets, bedding, and enrichment products under the Company's Teklad product line.
Bioproducts revenue represents the sale of serum and plasma, whole blood,
tissues, organs and glands, embryo culture serum and growth factors. Product
revenue is recognized at the point in time when the Company's performance
obligations with the applicable customers have been satisfied. Revenue is
recorded at the transaction price, which is the amount of consideration the
Company expects to receive in exchange for transferring products to a customer.
The performance obligations, including associated freight to deliver products,
are met based agreed upon terms, which are generally upon delivery (destination
point) and transfer of title. The Company determines the transaction price based
on fixed consideration in its contractual agreements. In determining the
transaction price, a significant financing component does not exist since the
timing from when the Company delivers product to when the customers pay for the
product is less than one year.

Income Taxes


The Company uses the asset and liability approach for financial accounting and
reporting of income taxes. Deferred income taxes reflect the net tax effect of
temporary differences between the carrying amount of assets and liabilities for
financial reporting purposes and the amounts used for income tax purposes.
Deferred taxes are measured using rates expected to apply to taxable income in
years in which those temporary differences are expected to reverse. The effect
of a change in tax rates on deferred tax assets and liabilities is recognized in
income in the period that includes the enactment date.

The Company recognizes deferred tax assets to the extent that it believes that
these assets are more likely than not to be realized. In making such a
determination, we consider all available positive and negative evidence,
including future reversals of existing taxable temporary differences, projected
future taxable income, tax-planning strategies, and results of recent
operations. If the Company determines that it would be able to realize its
deferred tax assets in the future in excess of its net recorded amount, the
Company would make an adjustment to the deferred tax asset valuation allowance,
which would reduce the provision for income taxes.

The Company uses a two-step process for the measurement of uncertain tax
positions that have been taken or are expected to be taken in a tax return. The
first step is a determination of whether the tax position should be recognized
in the consolidated financial statements. The second step determines the
measurement of the tax position. The Company records potential interest and
penalties on uncertain tax positions as a component of income tax expense.

As of November 5, 2021, with the acquisition of Envigo, the Company adopted an
accounting policy regarding the treatment of taxes due on future inclusion of
non-U.S. income in U.S. taxable income under the Global Intangible Low-Taxed
Income provisions as a current period expense when incurred.

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Goodwill and Intangible Assets



We use assumptions and estimates in determining the fair value of assets
acquired and liabilities assumed in a business combination. The determination of
the fair value of intangible assets, which represent a significant portion of
the purchase price in many of our acquisitions, requires the use of significant
judgment with regard to the fair value. We utilize commonly accepted valuation
techniques, such as the income, cost and market approaches, as appropriate, in
establishing the fair value of intangible assets. Typically, key assumptions
include projections of cash flows that arise from identifiable intangible assets
of acquired businesses as well as discount rates based on an analysis of the
weighted average cost of capital, adjusted for specific risks associated with
the assets. Customer relationship intangible assets are the most significant
identifiable definite-lived asset acquired. To determine the fair value of the
acquired customer relationships, the Company typically utilizes the multiple
period excess earnings model (a commonly accepted valuation technique), which
relies on the following key assumptions: projections of cash flows from the
acquired entities, which includes future revenue growth rates, operating income
margins, and customer attrition rates; as well as discount rates based on an
analysis of the acquired entities' weighted average cost of capital.

Goodwill represents the difference between the purchase price and the fair value
of assets acquired and liabilities assumed when accounted for using the
acquisition method of accounting. Goodwill is not amortized, but reviewed for
impairment on an annual basis, utilizing an assessment date of September 30th,
or more frequently if an event occurs or circumstances change that would
more-likely-than-not reduce the fair value of the Company's reporting units
below their carrying amounts.

The Company has the option to first assess qualitative factors to determine
whether it is necessary to perform the quantitative impairment test. If the
Company elects this option and believes, as a result of the qualitative
assessment, that it is more-likely-than-not that the carrying value of goodwill
is not recoverable, the quantitative impairment test is required; otherwise, no
further testing is required. Alternatively, the Company may elect to not first
assess qualitative factors and immediately perform the quantitative impairment
test. In the quantitative test, the Company compares the fair value of its
reporting units to their carrying values. The estimated cash flows used to
determine the fair value of the reporting units used in the impairment test
requires significant judgment with respect to revenue growth, gross margin,
EBITDA margin, and weighted average cost of capital. If the carrying values of
the net assets assigned to the reporting units exceed the fair values of the
reporting units an impairment loss equal to the difference would be recorded.
See Note 6 for further discussion related to goodwill impairment charges during
the fiscal year ended September 30, 2022.

Definite-lived intangible assets are amortized over the pattern in which the
economic benefits of the intangible assets are utilized and qualitatively
reviewed for impairment whenever events or changes in circumstances indicate
that the carrying amount of the assets or asset group may not be recoverable. If
quantitative determination of recoverability is required, recoverability of
assets to be held and used is determined by the Company at the level for which
there are identifiable cash flows by comparison of the carrying amount of the
assets to future undiscounted net cash flows before interest expense and income
taxes expected to be generated by the assets. If the carrying amount exceeds the
outcome of the analysis of undiscounted cash flows, impairment is measured
through various valuation techniques including discounted cash flow models,
quoted market values, and third-party independent appraisals, as considered
necessary. In the event that such cash flows are not expected to be sufficient
to recover the carrying amount of the definite-lived intangible assets, the
definite-lived intangible assets are written-down to their fair values.

Long-lived Tangible Assets


Long-lived assets to be held and used are reviewed for impairment whenever
events or changes in circumstances indicate that the carrying amount of the
assets or asset group may not be recoverable. Determination of recoverability is
based on an estimate of undiscounted future cash flows resulting from the use of
the asset and its eventual disposition. In the event that such cash flows are
not expected to be sufficient to recover the carrying amount of the assets, the
assets are written-down to their fair values. Long-lived assets to be disposed
of are carried at fair value less costs to sell.

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Fair Value of Financial Instruments


The provisions of the Fair Value Measurements and Disclosure Topic defines fair
value, establishes a consistent framework for measuring fair value and provides
the disclosure requirements about fair value measurements. This Topic also
establishes a hierarchy for inputs used in measuring fair value that maximizes
the use of observable inputs and minimizes the use of unobservable inputs by
requiring that the most observable inputs be used when available. Observable
inputs are inputs that market participants would use in pricing the asset or
liability developed based on market data obtained from sources independent of
the Company. Unobservable inputs are inputs that reflect the Company's judgment
about the assumptions market participants would use in pricing the asset or
liability based on the best information available in the circumstances. The
hierarchy is broken down into three levels based on the inputs as follows:

? Level 1 - Valuations based on quoted prices for identical assets or liabilities

in active markets that the Company has the ability to access.

? Level 2 - Valuations based on quoted prices in markets that are not active or

for which all significant inputs are observable, either directly or indirectly.

? Level 3 - Valuations based on inputs that are unobservable and significant to

the overall fair value measurement.

Pension Costs

As a result of the Envigo acquisition, the Company has a defined benefit pension plan for one of its U.K. subsidiaries.


The projected benefit obligation and funded position of the defined benefit plan
is estimated by actuaries and the Company recognizes the funded status of its
defined benefit plan on its consolidated balance sheets and recognizes gains,
losses and prior service costs or credits that arise during the period that are
not recognized as components of net periodic benefit cost as a component of
accumulated other comprehensive income (loss), net of tax. The Company measures
plan assets and obligations as of the date of the Company's year-end
consolidated balance sheet, using assumptions to anticipate future events.

The expected return on plan assets is determined using the fair value or calculated value of plan assets.



Additional information about certain effects on net periodic benefit cost for
the next fiscal year that arise from delayed recognition of the gains or losses,
prior service costs or credits, and transition assets or obligations are
disclosed in the notes to the consolidated financial statements (see Note 9 -
Post-employment Benefits).

Our significant accounting policies, including new accounting pronouncements,
are described in more detail in Note 2 of the Notes to Consolidated Financial
Statements included in response to Item 8 of this Report.

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