Hoth Therapeutics, Inc. announced new in vitro data demonstrating the therapeutic potential of HT-003 to block acne pathogenic gene expression in human keratinocytes, the major cell type of the epidermis and the outermost of the layers of the skin. Toll-like receptor 2 (TLR2) is one of the most critical pathways for acne pathophysiology. The data generated from this series of in vitro experiments shows that TLR2 is significantly inhibited by HT-003, including in the presence of TLR2 agonists. Baseline expression of TLR2 and a critical transcription factor for skin inflammation (NF-KB) are inhibited by HT-003.