Certain Common Stock of Guardant Health, Inc. are subject to a Lock-Up Agreement Ending on 6-JAN-2021. These Common Stock will be under lockup for 91 days starting from 7-OCT-2020 to 6-JAN-2021. Details: The selling stockholder has entered into a lock up agreement with the underwriter prior to the commencement of this offering pursuant to which the selling stockholder, for a period of 90 days after the date of this prospectus supplement, may not, without the prior written consent of J.P. Morgan Securities LLC, offer, pledge, sell, contract to sell, sell any option or contract to purchase, purchase any option or contract to sell, grant any option, right or warrant to purchase, hedge, lend, or otherwise transfer or dispose of, directly or indirectly, any shares of common stock or any securities convertible into or exercisable or exchangeable for common stock, or publicly disclose the intention to make any offer, sale, pledge or disposition, enter into any swap or other agreement that transfers, in whole or in part, any of the economic consequences of ownership of the common stock or such other securities, whether any such transaction described in clause or above is to be settled by delivery of common stock or such other securities, in cash or otherwise, or make any demand for or exercise any right with respect to the registration of any shares of common stock or any security convertible into or exercisable or exchangeable for common stock.