Genovate Biotech announced the start of its clinical trial (NCT04446416) for the combination of FUS plus bevacizumab therapy. Researchers at Linkou Chang Gung Memorial Hospital are investigating the use of Neuronavigation-guided FUS to repeatedly and temporarily open the blood-brain barrier (BBB) and enhance bevacizumab's efficacy in patients with recurrent glioblastoma (rGBM). To date, the first patient has been enrolled and is undergoing treatment. Led by neurosurgeon Dr. Kuo-Chen Wei at Linkou Chang Gung Memorial Hospital, the clinical trial will evaluate the safety and preliminary efficacy of repeated FUS-induced BBB opening with bevacizumab using the company's NaviFUS System. NaviFUS System utilizes neuronavigation and prior patient CT/MR images to guide the FUS energy. Additionally, the system includes a real-time acoustic emissions monitoring function that can personalize a safe and optimal level of FUS energy treatment for each patient. The study plans to enroll six rGBM patients who will undergo biweekly bevacizumab treatment. Per the clinical trial protocol, patients will receive FUS treatment with every bevacizumab dose up to the 34th week or until further disease progression. The first patient enrolled in August, and preliminary monitoring from the initial bevacizumab with FUS treatments have shown the patient's condition is stable with no adverse events.