The featured paper is entitled “Dynamics of Serologic Change to Gluten in Celiac Disease Patients” (doi.org/10.3390/nu15245083). The manuscript benefits from one of the largest databases of CeD clinical results from several Phase 2 clinical trials for latiglutenase and addresses two issues: (i) the return to seropositivity for CeD patients who resume a gluten containing diet for diagnostic purposes and (ii) the correlation between two different tTG-IgA assays at their defined upper limit of normal (ULN) thresholds.
“Our focus on developing latiglutenase is bolstered by this groundbreaking CeD research, just one component of the scientific, clinical, and regulatory expertise in gastroenterological drug development that
“The research published in Nutrients highlights new tools that may serve as critical diagnostics for identifying seroactive patients and for monitoring the efficacy of latiglutenase,” stated
About Latiglutenase
Latiglutenase is an orally administered mixture of two minimally systemically absorbed gluten-specific recombinant proteases being developed as an oral biotherapeutic for celiac disease. In Phase 2a and 2b clinical trials, latiglutenase was shown to reduce the severity and frequency of symptoms as well as mitigate gluten-induced intestinal mucosal injury in celiac disease patients. The Phase 3 clinical development plan for latiglutenase has been reviewed by the GI Division of the
About Celiac Disease
Celiac disease is a chronic, hereditary autoimmune and inflammatory disease triggered by gluten consumption. Celiac disease is characterized by damage to the lining of the small intestine, causing malabsorption, gastrointestinal dysfunction, and debilitating symptoms. Over the course of a lifetime, untreated or poorly managed celiac disease is often associated with deteriorating general health, multiple serious intestinal and extra-intestinal medical complications, and increased morbidity and mortality. Celiac disease is a global disease and affects approximately 1% of the population worldwide and is increasing in prevalence with improved diagnostic tools and improved awareness.
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