Evofem Biosciences, Inc. announced enrollment of the first patient in a Phase 2b/3 clinical trial evaluating Amphora and its ability to prevent urogenital chlamydia and gonorrhea in women. Amphora is an investigational compound being studied for the prevention of certain reproductive tract infections and as an on-demand, non-hormonal vaginal contraceptive. AMPREVENCE, a Phase 2b/3 double-blinded placebo-controlled efficacy trial of Amphora for the prevention of acquisition of urogenital Chlamydia trachomatis infection in women, is intended to demonstrate Amphora’s ability to prevent urogenital acquisition of Chlamydia trachomatis (primary endpoint) and Neisseria gonorrhea (secondary endpoint). Approximately 850 women at up to 20 centers in the United States are expected to be enrolled for a four-month interventional period and subsequent one-month follow-up period. Evofem’s current Phase 3 clinical trial evaluating Amphora for the prevention of pregnancy is expected to be fully enrolled in late February of 2018 with data reported in the first quarter of 2019. AMPOWER is a single-arm, open-label, multicenter study in women aged 18-35 years and is evaluating the contraceptive efficacy and safety of Amphora Contraceptive Vaginal Gel. The trial is expected to enroll approximately 1,350 women at risk of pregnancy at over 100 centers in the United States. The primary endpoint is the contraceptive efficacy of Amphora over seven cycles of use.